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Tbio
IL22
Interleukin-22

Protein Classes
Protein Summary
Description
Cytokine that contributes to the inflammatory response in vivo. This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328087
  • ENSP00000329384
  • ENSG00000127318
  • ENST00000538666
  • ENSP00000442424

Symbol
  • ILTIF
  • ZCYTO18
  • TIFa
  • IL-21
  • IL-22
  • ILTIF
  • IL-TIF
  • IL-D110
  • zcyto18
  • TIFIL-23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
phenotype
0.79
protein domain
0.58
small molecule perturbation
0.58
disease
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.87   (req: < 5)
Gene RIFs: 277   (req: <= 3)
Antibodies: 876   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 502.87   (req: >= 5)
Gene RIFs: 277   (req: > 3)
Antibodies: 876   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
1
2
17
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
17
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 22
VGNC:5429
741423
Macaque
interleukin 22
718047
Mouse
MGI:1355307
50929
Mouse
MGI:2151139
116849
Rat
RGD:1561292
500836
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 22
Macaque
interleukin 22
Mouse
Mouse
Rat
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9GZX6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (160)
1 – 10 of 160
IL22RA1
Tbio
Novelty: 0.01107638
Score: 0.998
Data Source: Reactome,STRINGDB
IL22RA2
Tbio
Novelty: 0.03455127
Score: 0.988
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.983
Data Source: Reactome,STRINGDB
IL10RB
Tbio
Novelty: 0.00880915
Score: 0.977
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.97
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.949
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.948
Data Source: STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.948
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.944
Data Source: Reactome,STRINGDB
IL10RA
Tbio
Novelty: 0.00506068
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  502.87

PubMed score by year
PubTator Score  647.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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