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Tbio
ERFE
Erythroferrone

Protein Summary
Description
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000546354
  • ENSP00000442304
  • ENSG00000178752

Symbol
  • C1QTNF15
  • CTRP15
  • FAM132B
  • CTRP15
  • FAM132B
  • C1QTNF15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.19   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.19   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
1
2
81.7
hemoglobin measurement
2
1
2
72.4
red blood cell distribution width
2
1
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
81.7
hemoglobin measurement
2
72.4
red blood cell distribution width
2
69.1
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (34)
1 – 10 of 34
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.914553105
p_ni: 0.085446895
Score: 0.158
Data Source: BioPlex,STRINGDB
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.861246451
p_ni: 0.138753548
Data Source: BioPlex
LRP1
Tbio
Novelty: 0.00200788
p_int: 0.80290498
p_ni: 0.197031091
p_wrong: 0.000063929
Score: 0.176
Data Source: BioPlex,STRINGDB
EPO
Tbio
Novelty: 0.00013701
Score: 0.813
Data Source: STRINGDB
HAMP
Tbio
Novelty: 0.00035828
Score: 0.799
Data Source: STRINGDB
C1QL4
Tdark
Novelty: 0.37071722
Score: 0.704
Data Source: STRINGDB
TMPRSS6
Tchem
Family: Enzyme
Novelty: 0.00739906
Score: 0.7
Data Source: STRINGDB
TFR2
Tbio
Family: Enzyme
Novelty: 0.00480264
Score: 0.667
Data Source: STRINGDB
GDF15
Tbio
Novelty: 0.00098503
Score: 0.653
Data Source: STRINGDB
C1QTNF1
Tbio
Novelty: 0.03481761
Score: 0.633
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.19

PubMed score by year
PubTator Score  15.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer