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Tchem
NNMT
Nicotinamide N-methyltransferase

Protein Summary
Description
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299964
  • ENSP00000299964
  • ENSG00000166741
  • ENST00000535401
  • ENSP00000441434
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
small molecule perturbation
0.81
disease
0.63
gene perturbation
0.59
transcription factor
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.53   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 429   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.53   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2349526
chemical structure image
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Metabolism of amino acids and derivatives
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Metabolism of vitamins and cofactors
Protein-Protein Interactions (43)
1 – 10 of 43
CAVIN1
Tbio
Family: Enzyme
Novelty: 0.00780634
Score: 0.984
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.954
Data Source: STRINGDB
AOX1
Tbio
Family: Enzyme
Novelty: 0.0025823
Score: 0.954
Data Source: STRINGDB
FHL2
Tbio
Novelty: 0.00501273
Score: 0.951
Data Source: STRINGDB
S100A10
Tbio
Novelty: 0.00281525
Score: 0.942
Data Source: STRINGDB
NAMPT
Tchem
Family: Enzyme
Novelty: 0.00093316
Score: 0.936
Data Source: STRINGDB
CD38
Tclin
Family: Enzyme
Novelty: 0.00034991
Score: 0.923
Data Source: STRINGDB
BST1
Tbio
Family: Enzyme
Novelty: 0.01329061
Score: 0.914
Data Source: STRINGDB
PNP
Tclin
Family: Enzyme
Novelty: 0.0019084
Score: 0.911
Data Source: STRINGDB
AKAP12
Tbio
Family: Enzyme
Novelty: 0.00821862
Score: 0.76
Data Source: STRINGDB
Publication Statistics
PubMed Score  197.53

PubMed score by year
PubTator Score  117.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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