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Tclin
TSHR
Thyrotropin receptor

Protein Summary
Description
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity). The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342443
  • ENSP00000340113
  • ENSG00000165409
  • ENST00000554435
  • ENSP00000450549

Symbol
  • LGR3
  • LGR3
  • CHNG1
  • hTSHR-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
protein domain
0.85
disease
0.8
disease perturbation
0.79
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1466.7   (req: < 5)
Gene RIFs: 234   (req: <= 3)
Antibodies: 1081   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1466.7   (req: >= 5)
Gene RIFs: 234   (req: > 3)
Antibodies: 1081   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
thyrotropin alfa
no chemical structure image available
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.4
94.1
albuminuria
1
1
0
30.7
49.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
94.1
albuminuria
0
30.7
49.7
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Protein-Protein Interactions (221)
1 – 10 of 221
LAMA3
Tbio
Novelty: 0.00733792
p_int: 0.987295952
p_ni: 0.012676485
p_wrong: 0.000027563
Score: 0.247
Data Source: BioPlex,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.956270812
p_ni: 0.043729188
Score: 0.178
Data Source: BioPlex,STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
p_int: 0.951607631
p_ni: 0.003046031
p_wrong: 0.045346338
Score: 0.19
Data Source: BioPlex,STRINGDB
MOCOS
Tbio
Family: Enzyme
Novelty: 0.05022905
p_int: 0.946301273
p_ni: 0.053695012
p_wrong: 0.000003715
Score: 0.173
Data Source: BioPlex,STRINGDB
BORA
Tbio
Novelty: 0.0374925
p_int: 0.909799974
p_ni: 0.090061699
p_wrong: 0.000138328
Score: 0.189
Data Source: BioPlex,STRINGDB
PC
Tbio
Family: Enzyme
Novelty: 0.00271694
p_int: 0.878394362
p_ni: 0.121605638
Score: 0.525
Data Source: BioPlex,STRINGDB
MLF1
Tbio
Novelty: 0.0239522
p_int: 0.788598376
p_ni: 0.211401624
Data Source: BioPlex
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.769791223
p_ni: 0.230208777
Data Source: BioPlex
TSHB
Tbio
Novelty: 0.00194403
Score: 0.983
Data Source: Reactome,STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  1466.70

PubMed score by year
PubTator Score  2607.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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