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Tbio
CLTCL1
Clathrin heavy chain 2

Protein Summary
Description
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427926
  • ENSP00000441158
  • ENSG00000070371
  • ENST00000621271
  • ENSP00000485020

Symbol
  • CLH22
  • CLTCL
  • CLTD
  • CLTD
  • CHC22
  • CLH22
  • CLTCL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
protein domain
0.97
cell type or tissue
0.91
protein complex
0.83
cell line
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.22   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.22   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (24)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
Gene Ontology Terms (23)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (313)
1 – 10 of 313
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999998363
p_ni: 0.000001637
Score: 0.33
Data Source: BioPlex,STRINGDB
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.999997933
p_ni: 0.000002067
Score: 0.238
Data Source: BioPlex,STRINGDB
CLINT1
Tbio
Novelty: 0.00945381
p_int: 0.999994882
p_ni: 0.000005118
Score: 0.517
Data Source: BioPlex,STRINGDB
PICALM
Tbio
Novelty: 0.00800832
p_int: 0.999982724
p_ni: 0.000017276
Score: 0.983
Data Source: BioPlex,STRINGDB
HSPBP1
Tbio
Novelty: 0.01176285
p_int: 0.99983254
p_ni: 0.00016746
Score: 0.197
Data Source: BioPlex,STRINGDB
OR13A1
Tdark
Family: oGPCR
Novelty: 8.09174312
p_int: 0.998766559
p_ni: 0.001233441
Data Source: BioPlex
CCL21
Tbio
Novelty: 0.00130736
p_int: 0.998542021
p_ni: 0.001457979
Score: 0.178
Data Source: BioPlex,STRINGDB
CCDC27
Tdark
Novelty: 1.27912281
p_int: 0.998393667
p_ni: 0.001606333
Score: 0.177
Data Source: BioPlex,STRINGDB
PTP4A1
Tchem
Family: Enzyme
Novelty: 0.02863007
p_int: 0.998165768
p_ni: 0.001834232
Data Source: BioPlex
CUTA
Tbio
Novelty: 0.01771609
p_int: 0.997784224
p_ni: 0.002215776
Data Source: BioPlex
Publication Statistics
PubMed Score  19.22

PubMed score by year
PubTator Score  17.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer