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Tbio
PLD5
Inactive phospholipase D5

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
66.4
HIV-1 infection
1
1
1
66.4
age at onset
1
1
0
7.7
50.1
Myopia
1
1
0
7.7
50.1
refractive error measurement
1
1
0
7.7
50.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
66.4
HIV-1 infection
1
66.4
age at onset
0
7.7
50.1
Myopia
0
7.7
50.1
refractive error measurement
0
7.7
50.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase D family member 5
VGNC:8094
457858
Macaque
phospholipase D family member 5
706256
Mouse
MGI:2442056
319455
Rat
RGD:1562609
289270
Dog
phospholipase D family member 5
VGNC:44664
490372
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase D family member 5
Macaque
phospholipase D family member 5
Mouse
Rat
Dog
phospholipase D family member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N7P1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (24)
1 – 10 of 24
CEP170
Tbio
Novelty: 0.05342931
Score: 0.712
Data Source: STRINGDB
ZBTB18
Tbio
Family: TF
Novelty: 0.03802355
Score: 0.683
Data Source: STRINGDB
WDR64
Tdark
Novelty: 2.12579381
Score: 0.682
Data Source: STRINGDB
RGS7
Tbio
Novelty: 0.01643407
Score: 0.609
Data Source: STRINGDB
KBTBD2
Tdark
Novelty: 0.50755656
Score: 0.545
Data Source: STRINGDB
PLD6
Tbio
Family: Enzyme
Novelty: 0.02802141
Score: 0.542
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.531
Data Source: STRINGDB
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
Score: 0.53
Data Source: STRINGDB
ABHD4
Tbio
Family: Enzyme
Novelty: 0.1068785
Score: 0.496
Data Source: STRINGDB
CTTNBP2NL
Tbio
Novelty: 0.52774527
Score: 0.477
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.72

PubMed score by year
PubTator Score  6.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer