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Tbio
PHC1
Polyhomeotic-like protein 1

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000543824
  • ENSP00000440674
  • ENSG00000111752
  • ENST00000544916
  • ENSP00000437659

Symbol
  • EDR1
  • PH1
  • EDR1
  • HPH1
  • RAE28
  • MCPH11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
disease perturbation
0.83
PubMedID
0.77
transcription factor binding site profile
0.77
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.15   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.15   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
96.7
eosinophil count
2
2
2
77.3
waist-hip ratio
1
1
1
73.5
total cholesterol measurement
2
1
2
41.1
body height
1
1
1
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
96.7
eosinophil count
2
77.3
waist-hip ratio
1
73.5
total cholesterol measurement
2
41.1
body height
1
37.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polyhomeotic homolog 1
VGNC:13337
465374
Macaque
polyhomeotic homolog 1
722268
Mouse
MGI:103248
13619
Rat
RGD:1309203
312690
Dog
polyhomeotic homolog 1
VGNC:44477
610167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polyhomeotic homolog 1
Macaque
polyhomeotic homolog 1
Mouse
Rat
Dog
polyhomeotic homolog 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78364-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (176)
1 – 10 of 176
PCGF2
Tbio
Novelty: 0.02148755
p_int: 1
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
SCMH1
Tbio
Family: Epigenetic
Novelty: 0.14054708
p_int: 1
Score: 0.744
Data Source: BioPlex,STRINGDB
CBX8
Tchem
Family: Epigenetic
Novelty: 0.00205993
p_int: 0.999999997
p_ni: 3e-9
Score: 0.99
Data Source: BioPlex,STRINGDB
CBX2
Tchem
Family: Epigenetic
Novelty: 0.01952928
p_int: 0.99999999
p_ni: 6e-9
p_wrong: 4e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
PHC3
Tbio
Novelty: 0.00091911
p_int: 0.999999943
p_ni: 5.6e-8
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
NPTXR
Tbio
Novelty: 0.00727951
p_int: 0.999999908
p_ni: 2.1e-8
p_wrong: 7e-8
Score: 0.239
Data Source: BioPlex,STRINGDB
CBX4
Tchem
Family: Epigenetic
Novelty: 0.02681197
p_int: 0.999999844
p_ni: 1.56e-7
Score: 0.986
Data Source: BioPlex,STRINGDB
PHC2
Tbio
Novelty: 0.01943349
p_int: 0.9999998
p_ni: 2e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
CBX7
Tchem
Family: Epigenetic
Novelty: 0.01612606
p_int: 0.999991097
p_ni: 9.2e-8
p_wrong: 0.000008811
Score: 0.994
Data Source: BioPlex,STRINGDB
SFMBT2
Tdark
Family: Epigenetic
Novelty: 0.0481272
p_int: 0.999990425
p_ni: 2.11e-7
p_wrong: 0.000009364
Score: 0.444
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  65.15

PubMed score by year
PubTator Score  31.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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