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Tbio
DDX11
ATP-dependent DNA helicase DDX11

Protein Summary
Description
DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis (PubMed:10648783, PubMed:21854770, PubMed:23797032, PubMed:26089203, PubMed:26503245). Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction (PubMed:18499658, PubMed:22102414). The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities (PubMed:18499658). Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228264
  • ENSP00000228264
  • ENSG00000013573
  • ENST00000350437
  • ENSP00000309965
  • ENST00000435753
  • ENSP00000406799
  • ENST00000542838
  • ENSP00000443426
  • ENST00000545668
  • ENSP00000440402

Symbol
  • CHL1
  • CHLR1
  • KRG2
  • CHL1
  • KRG2
  • WABS
  • CHLR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
histone modification site profile
0.91
co-expressed gene
0.89
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.05   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.05   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (141)
1 – 10 of 141
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.999929427
p_ni: 0.000070573
Data Source: BioPlex
KBTBD4
Tdark
Novelty: 0.35515885
p_int: 0.999764707
p_ni: 0.000235246
p_wrong: 4.7e-8
Score: 0.159
Data Source: BioPlex,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.999708736
p_ni: 0.000291264
Data Source: BioPlex
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.999539465
p_ni: 0.000460534
Data Source: BioPlex
AVIL
Tbio
Novelty: 0.0175973
p_int: 0.999421261
p_ni: 0.000578739
p_wrong: 1e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.999252171
p_ni: 0.000747824
p_wrong: 5e-9
Data Source: BioPlex
TENT5A
Tbio
Novelty: 0.08412895
p_int: 0.998985883
p_ni: 0.001014116
p_wrong: 1e-9
Score: 0.299
Data Source: BioPlex,STRINGDB
IARS2
Tbio
Family: Enzyme
Novelty: 0.00854621
p_int: 0.995818336
p_ni: 0.004176554
p_wrong: 0.00000511
Score: 0.16
Data Source: BioPlex,STRINGDB
SKP2
Tbio
Family: Enzyme
Novelty: 0.00182658
p_int: 0.995362693
p_ni: 0.004637303
p_wrong: 4e-9
Score: 0.193
Data Source: BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty: 0.43694835
p_int: 0.994681537
p_ni: 0.003886065
p_wrong: 0.001432398
Data Source: BioPlex
Publication Statistics
PubMed Score  57.05

PubMed score by year
PubTator Score  28.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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