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Tbio
PDYN
Proenkephalin-B

Protein Summary
Description
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect. The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217305
  • ENSP00000217305
  • ENSG00000101327
  • ENST00000539905
  • ENSP00000440185
  • ENST00000540134
  • ENSP00000442259

Symbol
  • ADCA
  • PENKB
  • SCA23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
biological term
0.71
PubMedID
0.69
gene perturbation
0.66
chemical
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2945.63   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2945.63   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
G-protein activation
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
G-protein activation
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (364)
1 – 10 of 364
ACAD11
Tbio
Family: Enzyme
Novelty: 0.55263158
p_int: 0.999707951
p_ni: 0.000292049
Score: 0.167
Data Source: BioPlex,STRINGDB
LCN1
Tbio
Novelty: 0.00390954
p_int: 0.997820161
p_ni: 0.000155337
p_wrong: 0.002024502
Score: 0.311
Data Source: BioPlex,STRINGDB
TIMM8B
Tbio
Family: Enzyme
Novelty: 0.03272462
p_int: 0.994811707
p_ni: 0.005188292
p_wrong: 1e-9
Score: 0.54
Data Source: BioPlex,STRINGDB
TIMM13
Tdark
Family: Enzyme
Novelty: 0.01126365
p_int: 0.986451582
p_ni: 0.013548418
Score: 0.513
Data Source: BioPlex,STRINGDB
OPRM1
Tclin
Family: GPCR
Novelty: 0.00035782
Score: 0.994
Data Source: Reactome,STRINGDB
OPRK1
Tclin
Family: GPCR
Novelty: 0.00087396
Score: 0.992
Data Source: STRINGDB
OPRD1
Tclin
Family: GPCR
Novelty: 0.001182
Score: 0.992
Data Source: STRINGDB
OPRL1
Tchem
Family: GPCR
Novelty: 0.00075372
Score: 0.992
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.986
Data Source: STRINGDB
PNOC
Tbio
Novelty: 0.00138452
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  2945.63

PubMed score by year
PubTator Score  552.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFT
1-70
PSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREG
70-140
AESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGF
140-210
LRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
210-254
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA