Tbio PDYN Proenkephalin-B

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Neuropeptide / Proenkephalin-b

DTO Classes

Protein / Signaling / Hormone / Neuropeptide / Proenkephalin-b

Protein Summary

Description

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect. The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• P01213
• A8K0Q3

Gene Name

• PDYN

Ensembl ID

• ENST00000217305
• ENSP00000217305
• ENSG00000101327
• ENST00000539905
• ENSP00000440185
• ENST00000540134
• ENSP00000442259

Symbol

• ADCA
• PENKB
• SCA23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.84
biological term	0.71
PubMedID	0.69
gene perturbation	0.66
chemical	0.59

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2945.63   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2945.63   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (17)

Reactome (9)

KEGG (4)

PathwayCommons (3)

WikiPathways (1)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	G-protein activation	28 targets	R-HSA-202040
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
G-protein activation	28 targets	R-HSA-202040
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792

Gene Ontology Terms (9)

Functions (1)

Components (5)

Processes (3)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
opioid peptide activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (364)

Explore Interacting Targets

1 – 10 of 364

• See Interactions on String-DB

ACAD11

Tbio

Family: Enzyme

Novelty: 0.55263158

p_int: 0.999707951

p_ni: 0.000292049

Score: 0.167

Data Source: BioPlex,STRINGDB

LCN1

Tbio

Novelty: 0.00390954

p_int: 0.997820161

p_ni: 0.000155337

p_wrong: 0.002024502

Score: 0.311

Data Source: BioPlex,STRINGDB

TIMM8B

Tbio

Family: Enzyme

Novelty: 0.03272462

p_int: 0.994811707

p_ni: 0.005188292

p_wrong: 1e-9

Score: 0.54

Data Source: BioPlex,STRINGDB

TIMM13

Tdark

Family: Enzyme

Novelty: 0.01126365

p_int: 0.986451582

p_ni: 0.013548418

Score: 0.513

Data Source: BioPlex,STRINGDB

OPRM1

Tclin

Family: GPCR

Novelty: 0.00035782

Score: 0.994

Data Source: Reactome,STRINGDB

OPRK1

Tclin

Family: GPCR

Novelty: 0.00087396

Score: 0.992

Data Source: STRINGDB

OPRD1

Tclin

Family: GPCR

Novelty: 0.001182

Score: 0.992

Data Source: STRINGDB

OPRL1

Tchem

Family: GPCR

Novelty: 0.00075372

Score: 0.992

Data Source: STRINGDB

POMC

Tbio

Novelty: 0.00002654

Score: 0.986

Data Source: STRINGDB

PNOC

Tbio

Novelty: 0.00138452

Score: 0.979

Data Source: STRINGDB

Publication Statistics

PubMed Score  2945.63

PubMed score by year

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PubTator Score  552.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFT

1-70

PSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREG

70-140

AESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGF

140-210

LRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA

210-254

MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA

Find similar targets by:

Uniprot Keyword

3D-structure
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Disulfide bond
Endorphin
Neurodegeneration
Neuropeptide
Neurotransmitter
Opioid peptide