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Tbio
ATP2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Protein Summary
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity). This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cyt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308664
  • ENSP00000311186
  • ENSG00000174437
  • ENST00000539276
  • ENSP00000440045

Symbol
  • ATP2B
  • DD
  • DAR
  • ATP2B
  • SERCA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
molecular function
1
protein domain
1
transcription factor perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.12   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.12   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
1
1
1.1
88.2
self reported educational attainment
1
1
1
17.8
intelligence
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
88.2
self reported educational attainment
1
17.8
intelligence
1
17.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
VGNC:8342
452231
Macaque
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
710702
Mouse
MGI:88110
11938
Rat
RGD:2174
29693
Dog
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
VGNC:38254
403878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Macaque
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Mouse
Rat
Dog
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P16615-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (31)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Gene Ontology Terms (55)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (180)
1 – 10 of 180
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
Score: 0.991
Data Source: STRINGDB
ATP2A1
Tchem
Family: Transporter
Novelty: 0.00355092
Score: 0.991
Data Source: STRINGDB
PLN
Tbio
Novelty: 0.01615063
Score: 0.976
Data Source: STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.949
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.93
Data Source: STRINGDB
ATP1B1
Tclin
Family: Transporter
Novelty: 0.025056
Score: 0.929
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.928
Data Source: STRINGDB
NOTCH4
Tchem
Novelty: 0.00471643
Score: 0.902
Data Source: STRINGDB
RYR2
Tclin
Family: IC
Novelty: 0.00078796
Score: 0.887
Data Source: STRINGDB
ATP1B2
Tclin
Family: Transporter
Novelty: 0.02641193
Score: 0.831
Data Source: STRINGDB
Publication Statistics
PubMed Score  739.12

PubMed score by year
PubTator Score  328.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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