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Tbio
MPDZ
Multiple PDZ domain protein

Protein Summary
Description
Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319217
  • ENSP00000320006
  • ENSG00000107186
  • ENST00000381022
  • ENSP00000370410
  • ENST00000447879
  • ENSP00000415208
  • ENST00000536827
  • ENSP00000444151
  • ENST00000541718
  • ENSP00000439807

Symbol
  • MUPP1
  • HYC2
  • MUPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.79
disease perturbation
0.74
gene perturbation
0.73
PubMedID
0.68
cell type or tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.66   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.66   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
3
89.3
balding measurement
1
1
1
85.6
appendicular lean mass
1
1
1
70.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
89.3
balding measurement
1
85.6
appendicular lean mass
1
70.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
multiple PDZ domain crumbs cell polarity complex component
VGNC:4788
473169
Macaque
multiple PDZ domain crumbs cell polarity complex component
715817
Mouse
MGI:1343489
17475
Rat
RGD:3105
29365
Dog
multiple PDZ domain crumbs cell polarity complex component
VGNC:43332
474708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
multiple PDZ domain crumbs cell polarity complex component
Macaque
multiple PDZ domain crumbs cell polarity complex component
Mouse
Rat
Dog
multiple PDZ domain crumbs cell polarity complex component
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75970-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (121)
1 – 10 of 121
LIN7C
Tbio
Novelty: 0.06778878
p_int: 0.999999999
p_ni: 1e-9
Score: 0.765
Data Source: BioPlex,STRINGDB
MPP5
Tbio
Novelty: 0.01707773
p_int: 0.999999995
p_ni: 5e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
LIN7B
Tbio
Novelty: 0.12689192
p_int: 0.999999992
p_ni: 8e-9
Score: 0.293
Data Source: BioPlex,STRINGDB
FAM124A
Tdark
Novelty: 1.51577847
p_int: 0.999998724
p_ni: 0.000001276
Data Source: BioPlex
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.999769557
p_ni: 0.000230443
Score: 0.189
Data Source: BioPlex,STRINGDB
PLEKHG5
Tbio
Novelty: 0.01182841
Score: 0.895
Data Source: STRINGDB
AMOT
Tbio
Novelty: 0.01269856
Score: 0.769
Data Source: STRINGDB
SSTR3
Tclin
Family: GPCR
Novelty: 0.00899073
Score: 0.767
Data Source: STRINGDB
KCNV2
Tclin
Family: IC
Novelty: 0.02600406
Score: 0.754
Data Source: STRINGDB
HTR2C
Tclin
Family: GPCR
Novelty: 0.00074287
Score: 0.751
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.66

PubMed score by year
PubTator Score  38.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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