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Tbio
PDCD2
Programmed cell death protein 2

Protein Summary
Description
May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392090
  • ENSP00000375940
  • ENSG00000071994
  • ENST00000443345
  • ENSP00000397272
  • ENST00000453163
  • ENSP00000402524
  • ENST00000537445
  • ENSP00000440572
  • ENST00000541970
  • ENSP00000439467

Symbol
  • RP8
  • ZMYND7
  • RP8
  • ZMYND7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.9
histone modification site profile
0.88
kinase perturbation
0.84
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.12   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 2
VGNC:12688
465124
Macaque
programmed cell death 2
696380
Mouse
MGI:104643
18567
Rat
RGD:61887
58934
Dog
programmed cell death 2
VGNC:44337
475041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 2
Macaque
programmed cell death 2
Mouse
Rat
Dog
programmed cell death 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16342-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (83)
1 – 10 of 83
PRMT3
Tchem
Family: Epigenetic
Novelty: 0.03433797
p_int: 0.999998099
p_ni: 0.0000019
Score: 0.246
Data Source: BioPlex,STRINGDB
CERK
Tchem
Family: Kinase
Novelty: 0.0103948
p_int: 0.999973464
p_ni: 0.000026524
p_wrong: 1.2e-8
Data Source: BioPlex
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999973455
p_ni: 0.000026545
Data Source: BioPlex
ABHD18
Tdark
Novelty: 10.43528841
p_int: 0.999936409
p_ni: 0.000063591
Data Source: BioPlex
RPS2
Tbio
Novelty: 0.00412313
p_int: 0.999604622
p_ni: 0.000395378
Score: 0.557
Data Source: BioPlex,STRINGDB
ZNF277
Tbio
Novelty: 0.21739031
p_int: 0.999331041
p_ni: 0.000102721
p_wrong: 0.000566238
Data Source: BioPlex
CD59
Tbio
Novelty: 0.0008352
p_int: 0.997968548
p_ni: 0.002031425
p_wrong: 2.7e-8
Data Source: BioPlex
CD55
Tbio
Novelty: 0.0005689
p_int: 0.996218308
p_ni: 0.00364198
p_wrong: 0.000139712
Data Source: BioPlex
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
p_int: 0.996103087
p_ni: 0.003889213
p_wrong: 0.0000077
Data Source: BioPlex
PRDM10
Tbio
Family: TF; Epigenetic
Novelty: 0.03463517
p_int: 0.991442766
p_ni: 0.00855721
p_wrong: 2.5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  22.12

PubMed score by year
PubTator Score  154.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer