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Tbio
TRDN
Triadin

Protein Summary
Description
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334268
  • ENSP00000333984
  • ENSG00000186439
  • ENST00000542443
  • ENSP00000437684
  • ENST00000628709
  • ENSP00000486095

Symbol
  • TDN
  • CPVT5
  • TRISK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
cell type or tissue
0.76
cellular component
0.76
kinase perturbation
0.66
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.25   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.25   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
0
6.8
54.5
electrocardiography
1
1
2
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
0
6.8
54.5
electrocardiography
2
24.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
triadin
VGNC:52147
744745
Macaque
triadin
713373
Mouse
MGI:1924007
76757
Dog
triadin
VGNC:47791
403776
Zebrafish
ZDB-GENE-041014-193
100038781
Species
Name
OMA
EggNOG
Inparanoid
Chimp
triadin
Macaque
triadin
Mouse
Dog
triadin
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13061-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Gene Ontology Terms (28)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (155)
1 – 10 of 155
ABCC5
Tchem
Family: Transporter
Novelty: 0.00566605
p_int: 0.999995049
p_ni: 0.000003107
p_wrong: 0.000001844
Score: 0.192
Data Source: BioPlex,STRINGDB
TMEM205
Tdark
Novelty: 0.41048198
p_int: 0.99999401
p_ni: 0.000005989
p_wrong: 1e-9
Data Source: BioPlex
GOLIM4
Tbio
Novelty: 0.01923513
p_int: 0.999924966
p_ni: 0.000075033
p_wrong: 1e-9
Data Source: BioPlex
JPH1
Tbio
Novelty: 0.00931679
p_int: 0.999633518
p_ni: 0.000366478
p_wrong: 4e-9
Score: 0.832
Data Source: BioPlex,STRINGDB
ABCB10
Tbio
Family: Transporter
Novelty: 0.00351852
p_int: 0.999478502
p_ni: 0.000521498
Data Source: BioPlex
ZFPL1
Tbio
Novelty: 0.1829181
p_int: 0.999135342
p_ni: 0.000861565
p_wrong: 0.000003093
Data Source: BioPlex
TMEM223
Tdark
Novelty: 0.89146194
p_int: 0.998982064
p_ni: 0.00101689
p_wrong: 0.000001046
Data Source: BioPlex
TMEM9B
Tdark
Novelty: 0.56628366
p_int: 0.998422985
p_ni: 0.000008586
p_wrong: 0.001568429
Data Source: BioPlex
EMC3
Tbio
Novelty: 0.01113829
p_int: 0.996524045
p_ni: 0.003475955
Score: 0.666
Data Source: BioPlex,STRINGDB
VTI1B
Tbio
Novelty: 0.00955467
p_int: 0.995568602
p_ni: 0.004431384
p_wrong: 1.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  183.25

PubMed score by year
PubTator Score  25.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer