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Tdark
ZNF426
Zinc finger protein 426

Protein Summary
Description
May be involved in transcriptional regulation. Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253115
  • ENSP00000253115
  • ENSG00000130818
  • ENST00000535489
  • ENSP00000439017

Symbol
  • K-RBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.76
tissue sample
0.59
cell line
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (16)
1 – 10 of 16
TXLNA
Tbio
Novelty: 0.02549959
p_int: 0.999996948
p_ni: 0.000003052
Data Source: BioPlex
TXLNG
Tbio
Novelty: 0.08274423
p_int: 0.994286047
p_ni: 0.005713953
Data Source: BioPlex
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.933
Data Source: STRINGDB
PNMA5
Tdark
Novelty: 0.38868015
Score: 0.583
Data Source: STRINGDB
PNMA3
Tbio
Novelty: 0.00582151
Score: 0.524
Data Source: STRINGDB
FBXL12
Tdark
Novelty: 0.30007519
Score: 0.475
Data Source: STRINGDB
TBC1D21
Tdark
Novelty: 0.45203791
Score: 0.464
Data Source: STRINGDB
ZNF385B
Tbio
Novelty: 0.14389498
Score: 0.463
Data Source: STRINGDB
RBM14
Tbio
Novelty: 0.01286049
Score: 0.452
Data Source: STRINGDB
LRRC57
Tdark
Novelty: 5.85929893
Score: 0.451
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.38

PubMed score by year
PubTator Score  2.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer