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Tbio
ZCCHC8
Zinc finger CCHC domain-containing protein 8

Protein Classes
Protein Summary
Description
Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing (Probable). This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-te ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000536306
  • ENSP00000441423
  • ENSG00000033030
  • ENST00000543897
  • ENSP00000438993
  • ENST00000633063
  • ENSP00000488055
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor binding site profile
0.92
histone modification site profile
0.7
cell line
0.65
interacting protein
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
94.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
94.9
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (85)
1 – 10 of 85
RBM7
Tbio
Novelty: 0.07482689
p_int: 0.999978683
p_ni: 0.000021317
Score: 0.999
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.999782934
p_ni: 0.000217066
Data Source: BioPlex
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.999403851
p_ni: 0.000596147
p_wrong: 2e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.998881871
p_ni: 0.001118129
Score: 0.724
Data Source: BioPlex,STRINGDB
RBM11
Tbio
Novelty: 0.3223316
p_int: 0.998068399
p_ni: 0.001931601
Score: 0.856
Data Source: BioPlex,STRINGDB
EXOSC3
Tbio
Novelty: 0.03072164
p_int: 0.992769425
p_ni: 0.007230574
Score: 0.915
Data Source: BioPlex,STRINGDB
C1D
Tbio
Novelty: 0.00997109
p_int: 0.990033379
p_ni: 0.009966621
Score: 0.82
Data Source: BioPlex,STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.930129879
p_ni: 0.069866255
p_wrong: 0.000003866
Score: 0.9
Data Source: BioPlex,STRINGDB
RBM4B
Tdark
Novelty: 0.33151475
p_int: 0.921617366
p_ni: 0.078382634
Data Source: BioPlex
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
p_int: 0.89156205
p_ni: 0.108437949
Score: 0.897
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.82

PubMed score by year
PubTator Score  4.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer