Tclin CD19 B-lymphocyte antigen CD19

Protein Summary

Description

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15391
• A0N0P9
• F5H635
• Q96S68
• Q9BRD6

Gene Name

• CD19

Ensembl ID

• ENST00000324662
• ENSP00000313419
• ENSG00000177455
• ENST00000538922
• ENSP00000437940
• ENST00000567541
• ENSP00000456201

Symbol

• B4
• CVID3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.89
hub protein	0.79
cell type or tissue	0.76
cellular component	0.7
biological term	0.66

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3706.68   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 3891   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3706.68   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 3891   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

blinatumomab

CD19Tclin

ANTIBODY BINDING Kd: 9

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (30)

Reactome (17)

KEGG (5)

PathwayCommons (4)

WikiPathways (4)

Adaptive Immune System (R-HSA-1280218)

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Items per page:

5

1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695
Reactome	Complement cascade	133 targets	R-HSA-166658
Reactome	Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530
Reactome	Disease	1105 targets	R-HSA-1643685

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695
Complement cascade	133 targets	R-HSA-166658
Constitutive Signaling by Aberrant PI3K in Cancer	75 targets	R-HSA-2219530
Disease	1105 targets	R-HSA-1643685

Gene Ontology Terms (13)

Functions (1)

Components (5)

Processes (7)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (430)

Explore Interacting Targets

1 – 10 of 430

• See Interactions on String-DB

POLR2M

Tbio

Family: Enzyme

Novelty: 0.10421601

p_int: 0.999972195

p_ni: 0.000027805

Score: 0.169

Data Source: BioPlex,STRINGDB

MINDY3

Tbio

Novelty: 0.03965367

p_int: 0.999499256

p_ni: 0.000500744

Score: 0.207

Data Source: BioPlex,STRINGDB

B3GNT3

Tbio

Family: Enzyme

Novelty: 0.05453491

p_int: 0.998629257

p_ni: 0.000136099

p_wrong: 0.001234644

Score: 0.218

Data Source: BioPlex,STRINGDB

IGSF8

Tbio

Novelty: 0.04429601

p_int: 0.938865204

p_ni: 0.061134794

p_wrong: 2e-9

Score: 0.403

Data Source: BioPlex,STRINGDB

CD79A

Tbio

Novelty: 0.00192293

Score: 0.996

Data Source: STRINGDB

CR2

Tbio

Novelty: 0.00116781

Score: 0.996

Data Source: Reactome,STRINGDB

LYN

Tclin

Family: Kinase

Novelty: 0.00137519

Score: 0.994

Data Source: STRINGDB

CD79B

Tclin

Novelty: 0.00265318

Score: 0.993

Data Source: STRINGDB

CD81

Tchem

Novelty: 0.00157371

Score: 0.987

Data Source: Reactome,STRINGDB

BTK

Tclin

Family: Kinase

Novelty: 0.000673

Score: 0.984

Data Source: STRINGDB

Publication Statistics

PubMed Score  3706.68

PubMed score by year

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PubTator Score  2593.74

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPG

1-70

LGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRS

70-140

SEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRG

140-210

PLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVL

210-280

WHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGN

280-350

VLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEF

350-420

YENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSR

420-490

EATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR

490-556

MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR

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Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome