Protein Summary
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
- ENST00000324662
- ENSP00000313419
- ENSG00000177455
- ENST00000538922
- ENSP00000437940
- ENST00000567541
- ENSP00000456201
- B4
- CVID3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.89 | ||
hub protein | 0.79 | ||
cell type or tissue | 0.76 | ||
cellular component | 0.7 | ||
biological term | 0.66 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3706.68 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 3891 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3706.68 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 3891 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (30)
Reactome (17)
KEGG (5)
PathwayCommons (4)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 17
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | Complement cascade | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Complement cascade | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Disease | ||||
Gene Ontology Terms (13)
Functions (1)
Components (5)
Processes (7)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (430)
1 – 10 of 430
POLR2M
Family: Enzyme
Novelty: 0.10421601
p_int: 0.999972195
p_ni: 0.000027805
Score: 0.169
Data Source: BioPlex,STRINGDB
MINDY3
Novelty: 0.03965367
p_int: 0.999499256
p_ni: 0.000500744
Score: 0.207
Data Source: BioPlex,STRINGDB
B3GNT3
Family: Enzyme
Novelty: 0.05453491
p_int: 0.998629257
p_ni: 0.000136099
p_wrong: 0.001234644
Score: 0.218
Data Source: BioPlex,STRINGDB
IGSF8
Novelty: 0.04429601
p_int: 0.938865204
p_ni: 0.061134794
p_wrong: 2e-9
Score: 0.403
Data Source: BioPlex,STRINGDB
CD79A
Novelty: 0.00192293
Score: 0.996
Data Source: STRINGDB
CR2
Novelty: 0.00116781
Score: 0.996
Data Source: Reactome,STRINGDB
LYN
Family: Kinase
Novelty: 0.00137519
Score: 0.994
Data Source: STRINGDB
CD79B
Novelty: 0.00265318
Score: 0.993
Data Source: STRINGDB
CD81
Novelty: 0.00157371
Score: 0.987
Data Source: Reactome,STRINGDB
BTK
Family: Kinase
Novelty: 0.000673
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score 3706.68
PubMed score by year
PubTator Score 2593.74
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPG
1-70
LGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRS
70-140
SEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRG
140-210
PLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVL
210-280
WHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGN
280-350
VLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEF
350-420
YENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSR
420-490
EATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR
490-556
MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR
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