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Tbio
HMGA2
High mobility group protein HMGI-C

Protein Summary
Description
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characteriz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354636
  • ENSP00000346658
  • ENSG00000149948
  • ENST00000393578
  • ENSP00000377206
  • ENST00000403681
  • ENSP00000384026
  • ENST00000425208
  • ENSP00000407306
  • ENST00000537275
  • ENSP00000437747
  • ENST00000537429
  • ENSP00000443372

Symbol
  • HMGIC
  • BABL
  • LIPO
  • HMGIC
  • HMGI-C
  • STQTL9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
transcription factor perturbation
1
PubMedID
0.99
microRNA
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1057.81   (req: < 5)
Gene RIFs: 287   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1057.81   (req: >= 5)
Gene RIFs: 287   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 66
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
6
14
6.6
99.8
birth weight
6
5
7
99.3
appendicular lean mass
3
2
3
99.2
sex hormone-binding globulin measurement
5
3
5
98.4
cortical surface area measurement
1
2
0
716.5
96.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
14
6.6
99.8
birth weight
7
99.3
appendicular lean mass
3
99.2
sex hormone-binding globulin measurement
5
98.4
cortical surface area measurement
0
716.5
96.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
high mobility group AT-hook 2
717721
Mouse
MGI:101761
15364
Rat
RGD:620617
84017
Cow
high mobility group AT-hook 2
VGNC:29875
100297155
Anole lizard
high mobility group AT-hook 2
100555548
Species
Name
OMA
EggNOG
Inparanoid
Macaque
high mobility group AT-hook 2
Mouse
Rat
Cow
high mobility group AT-hook 2
Anole lizard
high mobility group AT-hook 2
Pathways (41)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
DNA Damage/Telomere Stress Induced Senescence
Reactome
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Gene Ontology Terms (72)
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (126)
1 – 10 of 126
RB1
Tchem
Novelty: 0.00063798
Score: 0.973
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.972
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.959
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.938
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.935
Data Source: STRINGDB
H1F0
Tchem
Novelty: 0.00039686
Score: 0.922
Data Source: Reactome,STRINGDB
HMGA1
Tbio
Family: TF
Novelty: 0.00185669
Score: 0.917
Data Source: Reactome,STRINGDB
LMNB1
Tbio
Novelty: 0.00127348
Score: 0.914
Data Source: STRINGDB
ASF1A
Tchem
Novelty: 0.02544466
Score: 0.912
Data Source: Reactome,STRINGDB
HIST1H1A
Tbio
Novelty: 0.00123818
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  1057.81

PubMed score by year
PubTator Score  516.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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