Tbio ENO2 Gamma-enolase

Protein Classes

PANTHER Classes

Protein / Lyase / Gamma-enolase

DTO Classes

Protein / Enzyme / Lyase / Gamma-enolase

Protein Summary

Description

Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09104
• B7Z2X9
• Q96J33

Gene Name

• ENO2

Ensembl ID

• ENST00000229277
• ENSP00000229277
• ENSG00000111674
• ENST00000535366
• ENSP00000437402
• ENST00000538763
• ENSP00000441490
• ENST00000541477
• ENSP00000438873

Symbol

• NSE
• HEL-S-279

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
interacting protein	0.9
hub protein	0.88
small molecule perturbation	0.88
protein domain	0.85

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4734.79   (req: < 5)

Gene RIFs: 132   (req: <= 3)

Antibodies: 1910   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4734.79   (req: >= 5)

Gene RIFs: 132   (req: > 3)

Antibodies: 1910   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (15)

1 – 5 of 15

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (20)

Reactome (5)

KEGG (6)

PathwayCommons (6)

UniProt (1)

WikiPathways (2)

Gluconeogenesis (R-HSA-70263)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gluconeogenesis	34 targets	R-HSA-70263
Reactome	Glucose metabolism	92 targets	R-HSA-70326
Reactome	Glycolysis	72 targets	R-HSA-70171
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of carbohydrates	293 targets	R-HSA-71387

Name	Explore in Pharos	Explore in Source
Gluconeogenesis	34 targets	R-HSA-70263
Glucose metabolism	92 targets	R-HSA-70326
Glycolysis	72 targets	R-HSA-70171
Metabolism	2112 targets	R-HSA-1430728
Metabolism of carbohydrates	293 targets	R-HSA-71387

Gene Ontology Terms (14)

Functions (2)

Components (9)

Processes (3)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
phosphopyruvate hydratase activity	Inferred from Sequence or structural Similarity (ISS)	CAFA
magnesium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (261)

Explore Interacting Targets

1 – 10 of 261

• See Interactions on String-DB

ENO3

Tbio

Family: Enzyme

Novelty: 0.00432053

p_int: 1

Score: 0.962

Data Source: BioPlex,STRINGDB

ENO1

Tchem

Family: Enzyme

Novelty: 0.00138287

p_int: 0.999959942

p_ni: 0.000040058

Score: 0.963

Data Source: BioPlex,STRINGDB

PGAM1

Tbio

Family: Enzyme

Novelty: 0.0137131

Score: 0.984

Data Source: STRINGDB

PKM

Tchem

Family: Kinase

Novelty: 0.00066016

Score: 0.981

Data Source: STRINGDB

PKLR

Tbio

Family: Kinase

Novelty: 0.00411221

Score: 0.98

Data Source: STRINGDB

GPI

Tbio

Family: Enzyme

Novelty: 0.00073017

Score: 0.972

Data Source: STRINGDB

PGAM2

Tbio

Family: Enzyme

Novelty: 0.02989704

Score: 0.964

Data Source: STRINGDB

BPGM

Tbio

Family: Enzyme

Novelty: 0.03453422

Score: 0.955

Data Source: STRINGDB

TPI1

Tbio

Family: Enzyme

Novelty: 0.00117277

Score: 0.955

Data Source: STRINGDB

PGK1

Tchem

Family: Kinase

Novelty: 0.00144192

Score: 0.945

Data Source: STRINGDB

Publication Statistics

PubMed Score  4734.79

PubMed score by year

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PubTator Score  2858.08

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHIN

1-70

STIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGN

70-140

SDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDE

140-210

GGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALY

210-280

QDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSV

280-350

TEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDE

350-420

ARFAGHNFRNPSVL

420-434

MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Glycolysis
Isopeptide bond
Lyase