Protein Classes
Protein Summary
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
- ENST00000229277
- ENSP00000229277
- ENSG00000111674
- ENST00000535366
- ENSP00000437402
- ENST00000538763
- ENSP00000441490
- ENST00000541477
- ENSP00000438873
- NSE
- HEL-S-279
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.94 | ||
interacting protein | 0.9 | ||
hub protein | 0.88 | ||
small molecule perturbation | 0.88 | ||
protein domain | 0.85 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4734.79 (req: < 5)
Gene RIFs: 132 (req: <= 3)
Antibodies: 1910 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4734.79 (req: >= 5)
Gene RIFs: 132 (req: > 3)
Antibodies: 1910 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (20)
Reactome (5)
KEGG (6)
PathwayCommons (6)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gluconeogenesis | ||||
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gluconeogenesis | ||||
Glucose metabolism | ||||
Glycolysis | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Gene Ontology Terms (14)
Functions (2)
Components (9)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | CAFA | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (261)
1 – 10 of 261
ENO3
Family: Enzyme
Novelty: 0.00432053
p_int: 1
Score: 0.962
Data Source: BioPlex,STRINGDB
ENO1
Family: Enzyme
Novelty: 0.00138287
p_int: 0.999959942
p_ni: 0.000040058
Score: 0.963
Data Source: BioPlex,STRINGDB
PGAM1
Family: Enzyme
Novelty: 0.0137131
Score: 0.984
Data Source: STRINGDB
PKM
Family: Kinase
Novelty: 0.00066016
Score: 0.981
Data Source: STRINGDB
PKLR
Family: Kinase
Novelty: 0.00411221
Score: 0.98
Data Source: STRINGDB
GPI
Family: Enzyme
Novelty: 0.00073017
Score: 0.972
Data Source: STRINGDB
PGAM2
Family: Enzyme
Novelty: 0.02989704
Score: 0.964
Data Source: STRINGDB
BPGM
Family: Enzyme
Novelty: 0.03453422
Score: 0.955
Data Source: STRINGDB
TPI1
Family: Enzyme
Novelty: 0.00117277
Score: 0.955
Data Source: STRINGDB
PGK1
Family: Kinase
Novelty: 0.00144192
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score 4734.79
PubMed score by year
PubTator Score 2858.08
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHIN
1-70
STIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGN
70-140
SDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDE
140-210
GGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALY
210-280
QDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSV
280-350
TEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDE
350-420
ARFAGHNFRNPSVL
420-434
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
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