Protein Summary
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
- ENST00000229277
- ENSP00000229277
- ENSG00000111674
- ENST00000535366
- ENSP00000437402
- ENST00000538763
- ENSP00000441490
- ENST00000541477
- ENSP00000438873
- NSE
- HEL-S-279
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
interacting protein | 0.9 | ||
hub protein | 0.88 | ||
small molecule perturbation | 0.88 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7071.06 (req: < 5)
Gene RIFs: 179 (req: <= 3)
Antibodies: 1910 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7071.06 (req: >= 5)
Gene RIFs: 179 (req: > 3)
Antibodies: 1910 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0