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Tbio
DICER1
Endoribonuclease Dicer

Protein Summary
Description
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carbox ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343455
  • ENSP00000343745
  • ENSG00000100697
  • ENST00000393063
  • ENSP00000376783
  • ENST00000526495
  • ENSP00000437256
  • ENST00000527414
  • ENSP00000435681
  • ENST00000541352
  • ENSP00000444719
  • ENST00000556045
  • ENSP00000451041

Symbol
  • DICER
  • HERNA
  • KIAA0928
  • DCR1
  • GLOW
  • MNG1
  • Dicer
  • HERNA
  • RMSE2
  • Dicer1e
  • K12H4.8-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
biological term
0.99
protein domain
0.97
microRNA
0.88


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GlyGen
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3492.29   (req: < 5)
Gene RIFs: 338   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3492.29   (req: >= 5)
Gene RIFs: 338   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
92.5
sex hormone-binding globulin measurement
2
1
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
92.5
sex hormone-binding globulin measurement
2
69.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dicer 1, ribonuclease III
VGNC:9155
453137
Macaque
dicer 1, ribonuclease III
702516
Mouse
MGI:2177178
192119
Rat
RGD:1309381
299284
Dog
dicer 1, ribonuclease III
VGNC:39958
480426
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dicer 1, ribonuclease III
Macaque
dicer 1, ribonuclease III
Mouse
Rat
Dog
dicer 1, ribonuclease III
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UPY3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
MicroRNA (miRNA) biogenesis
Reactome
Small interfering RNA (siRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Gene Ontology Terms (40)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (449)
1 – 10 of 449
AGO1
Tbio
Novelty: 0.00157424
p_int: 0.999931265
p_ni: 0.000068735
Score: 0.999
Data Source: BioPlex,STRINGDB
TRMT2A
Tbio
Family: Enzyme
Novelty: 0.15277091
p_int: 0.992184705
p_ni: 0.007815295
p_wrong: 1e-9
Score: 0.316
Data Source: BioPlex,STRINGDB
ADAMTS4
Tchem
Family: Enzyme
Novelty: 0.00424194
p_int: 0.991449089
p_ni: 0.008550911
Score: 0.158
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.990341936
p_ni: 0.009658063
p_wrong: 2e-9
Score: 0.311
Data Source: BioPlex,STRINGDB
PNKD
Tbio
Family: Enzyme
Novelty: 0.02456078
p_int: 0.989701644
p_ni: 0.010298356
Data Source: BioPlex
CPA6
Tbio
Family: Enzyme
Novelty: 0.05034597
p_int: 0.981268707
p_ni: 0.018731279
p_wrong: 1.3e-8
Score: 0.174
Data Source: BioPlex,STRINGDB
TRIM41
Tbio
Family: Enzyme
Novelty: 0.17238173
p_int: 0.97507686
p_ni: 0.02492314
Score: 0.264
Data Source: BioPlex,STRINGDB
HPSE2
Tbio
Family: Enzyme
Novelty: 0.00583615
p_int: 0.944396633
p_ni: 0.055603367
Data Source: BioPlex
PRG2
Tbio
Novelty: 0.00548995
p_int: 0.928858446
p_ni: 0.071141554
Data Source: BioPlex
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.927038237
p_ni: 0.072961763
Score: 0.286
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3492.29

PubMed score by year
PubTator Score  783.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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