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Tdark
CACNG5
Voltage-dependent calcium channel gamma-5 subunit

Protein Summary
Description
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307139
  • ENSP00000303092
  • ENSG00000075429
  • ENST00000533854
  • ENSP00000436836
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
cell type or tissue
0.62
cell line
0.53
metabolite
0.45
chemical
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Epstein Barr viral capsid antigen seropositivity
1
1
0
1.2
37.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Epstein Barr viral capsid antigen seropositivity
0
1.2
37.4
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2157946
140723
Rat
RGD:628805
140726
Dog
calcium voltage-gated channel auxiliary subunit gamma 5
VGNC:38650
490905
Cow
calcium voltage-gated channel auxiliary subunit gamma 5
VGNC:26690
529382
Anole lizard
calcium voltage-gated channel auxiliary subunit gamma 5
100568122
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit gamma 5
Cow
calcium voltage-gated channel auxiliary subunit gamma 5
Anole lizard
calcium voltage-gated channel auxiliary subunit gamma 5
Pathways (39)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Protein-Protein Interactions (132)
1 – 10 of 132
HELZ2
Tdark
Family: Enzyme
Novelty: 0.1810765
p_int: 0.999998096
p_ni: 0.000001903
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
ZNF142
Tdark
Family: TF
Novelty: 0.46019293
p_int: 0.999981943
p_ni: 0.000017992
p_wrong: 6.5e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
SCAI
Tbio
Novelty: 0.0021735
p_int: 0.999972749
p_ni: 0.000027241
p_wrong: 1e-8
Score: 0.17
Data Source: BioPlex,STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
p_int: 0.999954605
p_ni: 0.000045395
Data Source: BioPlex
ARHGEF39
Tdark
Novelty: 0.30447134
p_int: 0.999946614
p_ni: 0.000053188
p_wrong: 1.97e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
MIS18BP1
Tbio
Novelty: 0.05688807
p_int: 0.999883173
p_ni: 0.000116823
p_wrong: 5e-9
Data Source: BioPlex
THAP12
Tbio
Family: TF
Novelty: 0.21092098
p_int: 0.999462572
p_ni: 0.000537428
Data Source: BioPlex
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.99824334
p_ni: 0.00175666
Data Source: BioPlex
MCM10
Tbio
Novelty: 0.0136058
p_int: 0.998139955
p_ni: 0.001860045
Data Source: BioPlex
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
p_int: 0.997278519
p_ni: 0.002721481
Data Source: BioPlex
Publication Statistics
PubMed Score  2.83

PubMed score by year
PubTator Score  1.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer