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Tbio
GALNT4
Polypeptide N-acetylgalactosaminyltransferase 4

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG. This locus represents naturally occurring transcripts that splice the 5' exons of the POC1B (POC1 centriolar protein homolog B) gene on chromosome 12 to the GALNT4 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4) gene, which is located within a POC1B intron. Alternative splicing results in two transcript variants, one of which encodes a fusion isoform that shares sequence identity with the products of each individual gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000529983
  • ENSP00000436604
  • ENSG00000257594

Symbol
  • GALNT4
  • GalNAc-T4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
microRNA
0.8
tissue sample
0.71
transcription factor binding site profile
0.62
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.83   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Protein-Protein Interactions (55)
1 – 10 of 55
POC1B
Tbio
Novelty: 0.09023863
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.409
Data Source: BioPlex,STRINGDB
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.999999679
p_ni: 3.21e-7
Data Source: BioPlex
PIANP
Tbio
Novelty: 0.01739512
p_int: 0.999999622
p_ni: 3.78e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
APOF
Tbio
Novelty: 0.02636736
p_int: 0.99999593
p_ni: 0.000004046
p_wrong: 2.3e-8
Score: 0.538
Data Source: BioPlex,STRINGDB
MPPE1
Tbio
Family: Enzyme
Novelty: 0.16027847
p_int: 0.999400664
p_ni: 0.00016486
p_wrong: 0.000434476
Score: 0.171
Data Source: BioPlex,STRINGDB
GALNT7
Tbio
Family: Enzyme
Novelty: 0.05328171
p_int: 0.900886652
p_ni: 0.000847417
p_wrong: 0.098265931
Score: 0.837
Data Source: BioPlex,STRINGDB
ADPGK
Tbio
Family: Kinase
Novelty: 0.0552414
p_int: 0.861515983
p_ni: 0.002039627
p_wrong: 0.13644439
Score: 0.541
Data Source: BioPlex,STRINGDB
GAA
Tclin
Family: Enzyme
Novelty: 0.0063246
p_int: 0.856742907
p_ni: 0.000956333
p_wrong: 0.14230076
Score: 0.667
Data Source: BioPlex,STRINGDB
MUC1
Tbio
Novelty: 0.00024203
Score: 0.975
Data Source: STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.83

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer