You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TOR1AIP1
Torsin-1A-interacting protein 1

Protein Summary
Description
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528443
  • ENSP00000435365
  • ENSG00000143337
  • ENST00000606911
  • ENSP00000476687

Symbol
  • LAP1
  • LAP1
  • LAP1B
  • LGMD2Y
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor binding site profile
0.91
kinase perturbation
0.88
disease perturbation
0.87
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.49   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.49   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (62)
1 – 10 of 62
KLHL15
Tbio
Novelty: 0.54712519
p_int: 0.999166029
p_ni: 0.000833971
Score: 0.163
Data Source: BioPlex,STRINGDB
MAD2L1BP
Tbio
Novelty: 0.48374717
p_int: 0.991658253
p_ni: 0.005853373
p_wrong: 0.002488374
Score: 0.511
Data Source: BioPlex,STRINGDB
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.991613596
p_ni: 0.008386405
Score: 0.177
Data Source: BioPlex,STRINGDB
ATG4C
Tbio
Family: Enzyme
Novelty: 0.04175533
p_int: 0.839626894
p_ni: 0.160373107
Data Source: BioPlex
CA10
Tbio
Family: Enzyme
Novelty: 0.01053152
p_int: 0.839370635
p_ni: 0.160629365
Score: 0.207
Data Source: BioPlex,STRINGDB
AIFM1
Tbio
Novelty: 0.00940088
p_int: 0.801454933
p_ni: 0.198545067
Score: 0.187
Data Source: BioPlex,STRINGDB
TOR1A
Tbio
Novelty: 0.00056274
Score: 0.858
Data Source: STRINGDB
RIF1
Tbio
Novelty: 0.34360368
Score: 0.819
Data Source: STRINGDB
TOR3A
Tbio
Novelty: 0.11588309
Score: 0.713
Data Source: STRINGDB
CCDC120
Tbio
Novelty: 0.48574876
Score: 0.687
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.49

PubMed score by year
PubTator Score  47.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer