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Tbio
TEAD1
Transcriptional enhancer factor TEF-1

Protein Summary
Description
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. This gene encodes a ubiquitous transc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334310
  • ENSP00000334754
  • ENSG00000187079
  • ENST00000638666
  • ENSP00000491500

Symbol
  • TCF13
  • TEF1
  • AA
  • REF1
  • TCF13
  • TEF-1
  • NTEF-1
  • TCF-13
  • TEAD-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.85
transcription factor binding site profile
0.81
PubMedID
0.74
transcription factor perturbation
0.74
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.03   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.03   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
1
98.2
mathematical ability
1
1
1
79.4
appendicular lean mass
1
1
1
70.7
neutrophil count
2
2
2
68.9
cognitive function measurement
1
1
1
67.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
1
98.2
mathematical ability
1
79.4
appendicular lean mass
1
70.7
neutrophil count
2
68.9
cognitive function measurement
1
67.2
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX3 regulates YAP1-mediated transcription
Reactome
Transcriptional regulation by RUNX3
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX3 regulates YAP1-mediated transcription
Transcriptional regulation by RUNX3
Gene Ontology Terms (21)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (69)
1 – 10 of 69
TEAD4
Tbio
Family: TF
Novelty: 0.0114979
p_int: 0.999999997
p_ni: 3e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
p_int: 0.999999985
p_wrong: 1.4e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
VGLL4
Tbio
Novelty: 0.03384856
p_int: 0.999999772
p_ni: 1.77e-7
p_wrong: 5.2e-8
Score: 0.97
Data Source: BioPlex,STRINGDB
WWTR1
Tbio
Novelty: 0.00431186
p_int: 0.99999911
p_ni: 8.85e-7
p_wrong: 5e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RAD51
Tchem
Novelty: 0.00011516
p_int: 0.977951525
p_ni: 0.022046363
p_wrong: 0.000002111
Score: 0.513
Data Source: BioPlex,STRINGDB
YAP1
Tbio
Novelty: 0.00124225
Score: 0.998
Data Source: Reactome,STRINGDB
CTGF
Tbio
Novelty: 0.0004346
Score: 0.965
Data Source: STRINGDB
VGLL1
Tbio
Novelty: 0.00731532
Score: 0.952
Data Source: STRINGDB
VGLL3
Tbio
Novelty: 0.04210787
Score: 0.933
Data Source: STRINGDB
VGLL2
Tbio
Novelty: 0.06797134
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.03

PubMed score by year
PubTator Score  120.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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