Tbio BCLAF1 Bcl-2-associated transcription factor 1

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Bcl-2-associated Transcription Factor 1

Protein Summary

Description

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYF8
• A2RU75
• B7ZM58
• E1P586
• Q14673
• Q86WU6
• Q86WY0
• Btf

Gene Name

• BCLAF1

Ensembl ID

• ENST00000353331
• ENSP00000229446
• ENSG00000029363
• ENST00000392348
• ENSP00000376159
• ENST00000527759
• ENSP00000434826
• ENST00000530767
• ENSP00000436501
• ENST00000531224
• ENSP00000435210

Symbol

• BTF
• KIAA0164
• BTF
• bK211L9.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
interacting protein	1
transcription factor perturbation	0.97
transcription factor binding site profile	0.94
hub protein	0.92

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.31   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.31   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (1)

WikiPathways (1)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Interactome of polycomb repressive complex 2 (PRC2)	23 targets	WP2916_r104425

Name	Explore in Pharos	Explore in Source
Interactome of polycomb repressive complex 2 (PRC2)	23 targets	WP2916_r104425

Gene Ontology Terms (14)

Functions (2)

Components (4)

Processes (8)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	MGI
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (111)

Explore Interacting Targets

1 – 10 of 111

• See Interactions on String-DB

CLK2

Tchem

Family: Kinase

Novelty: 0.36216831

p_int: 0.993636665

p_ni: 0.006363335

Score: 0.732

Data Source: BioPlex,STRINGDB

ERH

Tbio

Novelty: 0.00493543

p_int: 0.993598491

p_ni: 0.006401509

Score: 0.503

Data Source: BioPlex,STRINGDB

SAP18

Tbio

Family: Enzyme

Novelty: 0.05845743

p_int: 0.991281915

p_ni: 0.008718085

Score: 0.264

Data Source: BioPlex,STRINGDB

SNRNP70

Tbio

Novelty: 0.00199593

p_int: 0.987444316

p_ni: 0.012555684

Score: 0.457

Data Source: BioPlex,STRINGDB

SNIP1

Tbio

Novelty: 0.0303933

p_int: 0.969814333

p_ni: 0.030185667

Score: 0.685

Data Source: BioPlex,STRINGDB

LUC7L2

Tdark

Novelty: 0.46134191

p_int: 0.961290093

p_ni: 0.038709907

Score: 0.237

Data Source: BioPlex,STRINGDB

PNN

Tbio

Novelty: 0.00945912

p_int: 0.947388808

p_ni: 0.052611192

Score: 0.776

Data Source: BioPlex,STRINGDB

LARP4B

Tbio

Novelty: 0.153294

p_int: 0.938491276

p_ni: 0.061508725

Data Source: BioPlex

PRMT8

Tchem

Family: Epigenetic

Novelty: 0.05036347

p_int: 0.934774799

p_ni: 0.065225201

Data Source: BioPlex

RNASEH1

Tchem

Family: Enzyme

Novelty: 0.04998588

p_int: 0.920572197

p_ni: 0.079427803

Data Source: BioPlex

Publication Statistics

PubMed Score  220.31

PubMed score by year

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PubTator Score  27.22

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRNNRGMRRP

1-70

YGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPR

70-140

SSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSG

140-210

DIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNG

210-280

SSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLL

280-350

DRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQG

350-420

KSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITV

420-490

KKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSN

490-560

RPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNE

560-630

RFTSYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRR

630-700

RKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESK

700-770

KEREEEFKTHHEMKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYT

770-840

PKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEE

840-910

KKDRRKEEKE

910-920

MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQGKSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESKKEREEEFKTHHEMKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYTPKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEEKKDRRKEEKE

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Uniprot Keyword

Acetylation
Alternative splicing
Citrullination
Complete proteome
Cytoplasm
Direct protein sequencing
DNA-binding
Isopeptide bond
Methylation
Nucleus