Tbio BCLAF1 Bcl-2-associated transcription factor 1

Protein Summary

Description

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYF8
• A2RU75
• B7ZM58
• E1P586
• Q14673
• Q86WU6
• Q86WY0
• Btf

Gene Name

• BCLAF1

Ensembl ID

• ENST00000353331
• ENSP00000229446
• ENSG00000029363
• ENST00000392348
• ENSP00000376159
• ENST00000527759
• ENSP00000434826
• ENST00000530767
• ENSP00000436501
• ENST00000531224
• ENSP00000435210

Symbol

• BTF
• KIAA0164
• BTF
• bK211L9.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
interacting protein	1
transcription factor perturbation	0.97
transcription factor binding site profile	0.94
hub protein	0.92

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Bcl-2-associated Transcription Factor 1

DTO Classes

Protein / Transcription Factor / Bcl-2-associated Transcription Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.27   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 281   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.27   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (111)

Explore Interacting Targets

1 – 10 of 111

• See Interactions on String-DB

CLK2

Tchem

Family:  Kinase

Novelty:  0.13068449

p_int:  0.993636665

p_ni:  0.006363335

Score:  0.732

Data Source:  BioPlex,STRINGDB

ERH

Tbio

Novelty:  0.00711649

p_int:  0.993598491

p_ni:  0.006401509

Score:  0.503

Data Source:  BioPlex,STRINGDB

SAP18

Tbio

Family:  Enzyme

Novelty:  0.03918373

p_int:  0.991281915

p_ni:  0.008718085

Score:  0.264

Data Source:  BioPlex,STRINGDB

SNRNP70

Tbio

Novelty:  0.00116631

p_int:  0.987444316

p_ni:  0.012555684

Score:  0.457

Data Source:  BioPlex,STRINGDB

SNIP1

Tbio

Novelty:  0.01865867

p_int:  0.969814333

p_ni:  0.030185667

Score:  0.685

Data Source:  BioPlex,STRINGDB

LUC7L2

Tdark

Novelty:  0.36989457

p_int:  0.961290093

p_ni:  0.038709907

Score:  0.237

Data Source:  BioPlex,STRINGDB

PNN

Tbio

Novelty:  0.01395394

p_int:  0.947388808

p_ni:  0.052611192

Score:  0.776

Data Source:  BioPlex,STRINGDB

LARP4B

Tbio

Novelty:  0.11363794

p_int:  0.938491276

p_ni:  0.061508725

Data Source:  BioPlex

PRMT8

Tchem

Family:  Epigenetic

Novelty:  0.04213384

p_int:  0.934774799

p_ni:  0.065225201

Data Source:  BioPlex

RNASEH1

Tchem

Family:  Enzyme

Novelty:  0.01838314

p_int:  0.920572197

p_ni:  0.079427803

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

WikiPathways (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Interactome of polycomb repressive complex 2 (PRC2)	23 targets	WP2916_r104425

Name	Explore in Pharos	Explore in Source
Interactome of polycomb repressive complex 2 (PRC2)	23 targets	WP2916_r104425

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (2)

Components (4)

Processes (8)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	MGI
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Citrullination
Complete proteome
Cytoplasm
Direct protein sequencing
DNA-binding
Isopeptide bond
Methylation
Nucleus

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
limbs/digits/tail phenotype
mortality/aging
respiratory system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	BCL2 associated transcription factor 1	VGNC:7163	463020
Macaque	BCL2 associated transcription factor 1		705705
Mouse	BCL2-associated transcription factor 1	MGI:1917580	72567
Dog	BCL2 associated transcription factor 1	VGNC:38415	483999
Horse	BCL2 associated transcription factor 1	VGNC:15798	100067787

Species	Name	OMA	EggNOG	Inparanoid
Chimp	BCL2 associated transcription factor 1
Macaque	BCL2 associated transcription factor 1
Mouse	BCL2-associated transcription factor 1
Dog	BCL2 associated transcription factor 1
Horse	BCL2 associated transcription factor 1

Publication Statistics

PubMed Score 69.27

PubMed score by year

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PubTator Score 27.22

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (20)

Items per page:

10

0 of 0

PMID	Year	Title