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Tbio
TSKU
Tsukushin

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333090
  • ENSP00000332668
  • ENSG00000182704
  • ENST00000527881
  • ENSP00000434847
  • ENST00000612930
  • ENSP00000482145

Symbol
  • E2IG4
  • LRRC54
  • TSK
  • TSK
  • E2IG4
  • LRRC54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.85
transcription factor perturbation
0.84
transcription factor binding site profile
0.82
transcription factor
0.76
cell type or tissue
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.31   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.31   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
89.9
1
1
0
1
54.5
cognitive function measurement
1
1
1
52
factor VII measurement
1
1
1
43.5
1
1
1
43
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
89.9
0
1
54.5
cognitive function measurement
1
52
factor VII measurement
1
43.5
1
43
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tsukushi, small leucine rich proteoglycan
VGNC:12761
451436
Macaque
tsukushi, small leucine rich proteoglycan
697691
Mouse
MGI:2443855
244152
Rat
RGD:1359311
308843
Dog
tsukushi, small leucine rich proteoglycan
VGNC:52857
485178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tsukushi, small leucine rich proteoglycan
Macaque
tsukushi, small leucine rich proteoglycan
Mouse
Rat
Dog
tsukushi, small leucine rich proteoglycan
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WUA8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (58)
1 – 10 of 58
UXS1
Tbio
Family: Enzyme
Novelty: 0.04671281
p_int: 0.999958543
p_ni: 8e-9
p_wrong: 0.000041449
Score: 0.222
Data Source: BioPlex,STRINGDB
TES
Tbio
Novelty: 0.00052221
Score: 0.844
Data Source: STRINGDB
ADGRL1
Tbio
Family: GPCR
Novelty: 0.00957739
Score: 0.685
Data Source: STRINGDB
ADGRL2
Tbio
Family: GPCR
Novelty: 0.00985539
Score: 0.685
Data Source: STRINGDB
ADGRL3
Tbio
Family: GPCR
Novelty: 0.00268343
Score: 0.685
Data Source: STRINGDB
PMCH
Tbio
Novelty: 0.00600873
Score: 0.643
Data Source: STRINGDB
HSPA13
Tbio
Novelty: 0.03895652
Score: 0.601
Data Source: STRINGDB
FBN1
Tbio
Novelty: 0.00074957
Score: 0.591
Data Source: STRINGDB
PXDN
Tbio
Novelty: 0.00935722
Score: 0.587
Data Source: STRINGDB
LRRC20
Tdark
Novelty: 3.82267008
Score: 0.583
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.31

PubMed score by year
PubTator Score  609.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer