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Tbio
FCGR3B
Low affinity immunoglobulin gamma Fc region receptor III-B

Protein Classes
Protein Summary
Description
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294800
  • ENSP00000294800
  • ENSG00000162747
  • ENST00000367964
  • ENSP00000356941

Symbol
  • CD16B
  • FCG3
  • FCGR3
  • IGFR3
  • CD16
  • FCG3
  • CD16A
  • CD16b
  • FCGR3
  • FCGR3A
  • FCR-10
  • FCRIII
  • FCRIIIb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.81
biological term
0.79
microRNA
0.79
PubMedID
0.74
disease
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2078.76   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2078.76   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
80.3
neutrophil count
3
2
3
76.6
basophil count
2
2
3
73.1
basophil percentage of leukocytes
1
2
2
69.1
leukocyte count
2
3
3
62.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
80.3
neutrophil count
3
76.6
basophil count
3
73.1
basophil percentage of leukocytes
2
69.1
leukocyte count
3
62.9
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Post-translational modification: synthesis of GPI-anchored proteins
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (159)
1 – 10 of 159
KLHL20
Tbio
Novelty: 0.12205871
p_int: 0.999810382
p_ni: 2.7e-8
p_wrong: 0.000189591
Data Source: BioPlex
LRRC8C
Tbio
Novelty: 0.11920205
p_int: 0.999518124
p_ni: 0.00048186
p_wrong: 1.6e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
ICK
Tchem
Family: Kinase
Novelty: 0.00810476
p_int: 0.987816485
p_ni: 0.010481735
p_wrong: 0.00170178
Score: 0.186
Data Source: BioPlex,STRINGDB
LRRC8E
Tbio
Novelty: 0.15689344
p_int: 0.984797784
p_ni: 0.015202213
p_wrong: 3e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
NPTX1
Tbio
Novelty: 0.02872516
p_int: 0.957837054
p_ni: 0.042162946
Data Source: BioPlex
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.95689816
p_ni: 0.04310184
Data Source: BioPlex
TUBB8
Tclin
Novelty: 0.06403117
p_int: 0.949487421
p_ni: 0.050512569
p_wrong: 1e-8
Data Source: BioPlex
NRP2
Tbio
Novelty: 0.00764179
p_int: 0.930628064
p_ni: 0.068502622
p_wrong: 0.000869314
Score: 0.183
Data Source: BioPlex,STRINGDB
COX16
Tbio
Family: Enzyme
Novelty: 0.20901823
p_int: 0.910410159
p_ni: 0.089505875
p_wrong: 0.000083966
Score: 0.206
Data Source: BioPlex,STRINGDB
ATP12A
Tchem
Family: Transporter
Novelty: 0.00008793
p_int: 0.893487174
p_ni: 0.106512826
Data Source: BioPlex
Publication Statistics
PubMed Score  2078.76

PubMed score by year
PubTator Score  175.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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