Tbio CFL1 Cofilin-1

Protein Summary

Description

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• P23528
• B3KUQ1
• Q53Y87
• Q9UCA2

Gene Name

• CFL1

Ensembl ID

• ENST00000308162
• ENSP00000309629
• ENSG00000172757
• ENST00000525451
• ENSP00000432660

Symbol

• CFL
• CFL
• cofilin
• HEL-S-15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
biological process	0.98
transcription factor binding site profile	0.98
biological term	0.95
hub protein	0.95

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1412.32   (req: < 5)

Gene RIFs: 149   (req: <= 3)

Antibodies: 963   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1412.32   (req: >= 5)

Gene RIFs: 149   (req: > 3)

Antibodies: 963   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (6)

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (41)

Reactome (23)

KEGG (5)

PathwayCommons (7)

WikiPathways (6)

Axon guidance (R-HSA-422475)

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Items per page:

5

1 – 5 of 23

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Gene Ontology Terms (34)

Functions (2)

Components (14)

Processes (18)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	UniProtKB
signaling receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (353)

Explore Interacting Targets

1 – 10 of 353

• See Interactions on String-DB

CAP2

Tbio

Family: Enzyme

Novelty: 0.21052632

p_int: 0.999720318

p_ni: 0.000279682

Score: 0.927

Data Source: BioPlex,STRINGDB

CAP1

Tbio

Family: Enzyme

Novelty: 0.03666609

p_int: 0.963118194

p_ni: 0.036881806

Score: 0.957

Data Source: BioPlex,STRINGDB

ACTBL2

Tbio

Novelty: 0.35273907

p_int: 0.879026561

p_ni: 0.120973439

Score: 0.598

Data Source: BioPlex,STRINGDB

ACTB

Tbio

Novelty: 0.00027728

Score: 0.999

Data Source: STRINGDB

LIMK1

Tchem

Family: Kinase

Novelty: 0.0046681

Score: 0.997

Data Source: Reactome,STRINGDB

ACTG1

Tbio

Novelty: 0.00111542

Score: 0.997

Data Source: STRINGDB

SSH1

Tbio

Family: Enzyme

Novelty: 0.02721177

Score: 0.993

Data Source: STRINGDB

ACTA1

Tbio

Novelty: 0.00147233

Score: 0.991

Data Source: STRINGDB

LIMK2

Tchem

Family: Kinase

Novelty: 0.0180473

Score: 0.991

Data Source: STRINGDB

RHOA

Tbio

Family: Enzyme

Novelty: 0.0002729

Score: 0.988

Data Source: STRINGDB

Publication Statistics

PubMed Score  1412.32

PubMed score by year

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PubTator Score  835.53

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYAT

1-70

FVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCY

70-140

EEVKDRCTLAEKLGGSAVISLEGKPL

140-166

MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Actin-binding
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Isopeptide bond