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Tbio
AMBRA1
Activating molecule in BECN1-regulated autophagy protein 1

Protein Summary
Description
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314845
  • ENSP00000318313
  • ENSG00000110497
  • ENST00000458649
  • ENSP00000415327
  • ENST00000528950
  • ENSP00000433945
  • ENST00000534300
  • ENSP00000431926

Symbol
  • KIAA1736
  • DCAF3
  • WDR94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
biological process
0.67
cellular component
0.67
tissue sample
0.65
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.12   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.12   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1
1
94.5
cigarettes per day measurement
1
1
1
73.6
3
2
1
1.1
65.4
bone density
1
1
1
37.4
intelligence
1
1
1
27.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
94.5
cigarettes per day measurement
1
73.6
1
1.1
65.4
bone density
1
37.4
intelligence
1
27.6
Pathways (7)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Gene Ontology Terms (24)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (100)
1 – 10 of 100
RFPL4B
Tdark
Novelty: 2.42779597
p_int: 0.994097753
p_ni: 0.005902247
Data Source: BioPlex
SOCS3
Tbio
Novelty: 0.00106095
p_int: 0.990531659
p_ni: 0.009468341
Score: 0.379
Data Source: BioPlex,STRINGDB
HPS1
Tbio
Novelty: 0.44609665
p_int: 0.988140062
p_ni: 0.011859938
Score: 0.345
Data Source: BioPlex,STRINGDB
CISH
Tbio
Novelty: 0.00145893
p_int: 0.903923787
p_ni: 0.096076213
Score: 0.379
Data Source: BioPlex,STRINGDB
ANKRD9
Tdark
Novelty: 0.43181793
p_int: 0.876005435
p_ni: 0.123994565
Data Source: BioPlex
WSB2
Tbio
Novelty: 0.03939755
p_int: 0.871657494
p_ni: 0.128342506
Score: 0.189
Data Source: BioPlex,STRINGDB
ASB8
Tdark
Novelty: 0.44680949
p_int: 0.800286413
p_ni: 0.199713587
Score: 0.245
Data Source: BioPlex,STRINGDB
ELOA2
Tdark
Family: Enzyme
Novelty: 0.7420148
p_int: 0.769267256
p_ni: 0.230732744
Data Source: BioPlex
BECN1
Tbio
Novelty: 0.0003792
Score: 0.997
Data Source: Reactome,STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  70.12

PubMed score by year
PubTator Score  31.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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