You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
TYK2
Non-receptor tyrosine-protein kinase TYK2

Protein Summary
Description
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264818
  • ENSP00000264818
  • ENSG00000105397
  • ENST00000525621
  • ENSP00000431885

Symbol
  • JTK1
  • IMD35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
histone modification site profile
0.91
hub protein
0.85
transcription factor
0.76


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.42   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 665   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.42   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 665   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 166
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (166)
1 – 10 of 166
CHEMBL388978
chemical structure image
CHEMBL603469
chemical structure image
CHEMBL495727
chemical structure image
CHEMBL1908395,CHEMBL1908842
chemical structure image
CHEMBL3917405
chemical structure image
CHEMBL3780091,CHEMBL3780299
chemical structure image
cerdulatinib
chemical structure image
CHEMBL1944698
chemical structure image
CHEMBL3905686
chemical structure image
CHEMBL3981587
chemical structure image
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1
4
96.3
2
3
0
1.3
96.3
6
5
0
1.3
94.4
3
2
0
1.4
92.6
5
2
1
1.5
85.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
96.3
0
1.3
96.3
0
1.3
94.4
0
1.4
92.6
1
1.5
85.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosine kinase 2
VGNC:2210
455703
Macaque
tyrosine kinase 2
574130
Mouse
MGI:1929470
54721
Rat
RGD:2320469
100361294
Dog
tyrosine kinase 2
VGNC:48024
476714
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosine kinase 2
Macaque
tyrosine kinase 2
Mouse
Rat
Dog
tyrosine kinase 2
Protein Structure (24 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P29597-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (91)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (248)
1 – 10 of 248
IFT43
Tbio
Novelty: 0.00478274
p_int: 0.999974229
p_ni: 0.00002577
Data Source: BioPlex
PMEL
Tbio
Novelty: 0.00116525
p_int: 0.999826399
p_ni: 0.000173594
p_wrong: 7e-9
Data Source: BioPlex
RNF13
Tbio
Family: Enzyme
Novelty: 0.09764564
p_int: 0.999706444
p_ni: 0.000293555
Data Source: BioPlex
TNFRSF19
Tbio
Novelty: 0.01295599
p_int: 0.999703849
p_ni: 0.00029615
p_wrong: 1e-9
Data Source: BioPlex
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.999278671
p_ni: 0.000721329
Data Source: BioPlex
LRRC46
Tdark
Novelty: 1.159245
p_int: 0.997887943
p_ni: 0.002112057
Score: 0.21
Data Source: BioPlex,STRINGDB
IL4R
Tclin
Novelty: 0.00359183
p_int: 0.997514066
p_ni: 0.002485833
p_wrong: 1.02e-7
Score: 0.945
Data Source: BioPlex,Reactome,STRINGDB
TMCO3
Tdark
Novelty: 1.16719823
p_int: 0.993254088
p_ni: 0.006745911
p_wrong: 1e-9
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.986720156
p_ni: 0.013279842
p_wrong: 2e-9
Data Source: BioPlex
CDH8
Tbio
Novelty: 0.04055999
p_int: 0.986258001
p_ni: 0.013741999
Data Source: BioPlex
Publication Statistics
PubMed Score  357.42

PubMed score by year
PubTator Score  240.79

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: