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Tbio
MYBL1
Myb-related protein A

Protein Summary
Description
Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:8058310, PubMed:7987850). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000522677
  • ENSP00000429633
  • ENSG00000185697
  • ENST00000524176
  • ENSP00000428011

Symbol
  • AMYB
  • AMYB
  • A-MYB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
histone modification site profile
0.85
protein domain
0.85
microRNA
0.83
small molecule perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (12)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (106)
1 – 10 of 106
LIN9
Tbio
Novelty: 0.00193435
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.926
Data Source: BioPlex,STRINGDB
LIN37
Tbio
Novelty: 0.0949829
p_int: 0.999999903
p_ni: 3.5e-8
p_wrong: 6.3e-8
Score: 0.945
Data Source: BioPlex,STRINGDB
LIN52
Tbio
Novelty: 0.07934486
p_int: 0.999995648
p_ni: 6.79e-7
p_wrong: 0.000003674
Score: 0.951
Data Source: BioPlex,STRINGDB
LIN54
Tbio
Novelty: 0.04286437
p_int: 0.999994152
p_ni: 0.000005849
Score: 0.918
Data Source: BioPlex,STRINGDB
PCBP3
Tbio
Novelty: 0.13959602
p_int: 0.974897658
p_ni: 0.025102339
p_wrong: 3e-9
Data Source: BioPlex
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00127032
Score: 0.851
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.811
Data Source: STRINGDB
CEBPB
Tbio
Family: TF
Novelty: 0.00076161
Score: 0.805
Data Source: STRINGDB
CEBPA
Tbio
Family: TF
Novelty: 0.00103676
Score: 0.75
Data Source: STRINGDB
KMT2B
Tbio
Family: Epigenetic
Novelty: 0.0097804
Score: 0.747
Data Source: STRINGDB
Publication Statistics
PubMed Score  108.65

PubMed score by year
PubTator Score  48.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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