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Tbio
CEBPA
CCAAT/enhancer-binding protein alpha

Protein Summary
Description
Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000498907
  • ENSP00000427514
  • ENSG00000245848

Symbol
  • CEBP
  • CEBP
  • C/EBP-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
0.99
molecular function
0.99
virus
0.98
PubMedID
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1765.56   (req: < 5)
Gene RIFs: 344   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1765.56   (req: >= 5)
Gene RIFs: 344   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (295)
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.994543183
p_ni:  1e-9
p_wrong:  0.005456816
Score:  0.351
Data Source:  BioPlex,STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.982
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.981
Data Source:  STRINGDB
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.98
Data Source:  STRINGDB
ADIPOQ
Tbio
Novelty:  0.00011196
Score:  0.977
Data Source:  STRINGDB
KLF5
Tchem
Family:  TF
Novelty:  0.00384971
Score:  0.976
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.972
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.971
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.971
Data Source:  STRINGDB
FABP4
Tchem
Novelty:  0.00107707
Score:  0.969
Data Source:  STRINGDB
Pathways (26)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of granulopoiesis
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of granulopoiesis
Transcriptional regulation of white adipocyte differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (56)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
28
42
99
mean corpuscular volume
2
6
6
98.2
basophil count
7
6
11
98.1
waist-hip ratio
6
25
30
98.1
mean reticulocyte volume
1
5
5
97.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
42
99
mean corpuscular volume
6
98.2
basophil count
11
98.1
waist-hip ratio
30
98.1
mean reticulocyte volume
5
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99480
12606
Rat
RGD:2326
24252
Pig
CCAAT/enhancer binding protein alpha
397307
Platypus
CCAAT/enhancer binding protein alpha [Source:HGNC Symbol;Acc:HGNC:1833]
Xenopus
CCAAT enhancer binding protein alpha
XB-GENE-853397
496454
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Pig
CCAAT/enhancer binding protein alpha
Platypus
CCAAT/enhancer binding protein alpha [Source:HGNC Symbol;Acc:HGNC:1833]
Xenopus
CCAAT enhancer binding protein alpha
Publication Statistics
PubMed Score 1765.56
PubMed score by year
PubTator Score 1320.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title