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Tbio
CXCL2
C-X-C motif chemokine 2

Protein Summary
Description
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000508487
  • ENSP00000427279
  • ENSG00000081041

Symbol
  • GRO2
  • GROB
  • MIP2A
  • SCYB2
  • GRO2
  • GROb
  • MIP2
  • MIP2A
  • SCYB2
  • MGSA-b
  • MIP-2a
  • CINC-2a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
gene perturbation
1
virus perturbation
1
small molecule perturbation
0.89
histone modification site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.94   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.94   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
81.8
neutrophil percentage of leukocytes
1
1
1
59.6
lymphocyte percentage of leukocytes
1
1
1
59
basophil percentage of leukocytes
1
1
1
47.7
neutrophil percentage of granulocytes
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
81.8
neutrophil percentage of leukocytes
1
59.6
lymphocyte percentage of leukocytes
1
59
basophil percentage of leukocytes
1
47.7
neutrophil percentage of granulocytes
1
43.2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (55)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (361)
1 – 10 of 361
CXCL3
Tbio
Novelty: 0.01001656
p_int: 0.999998522
p_wrong: 0.000001479
Score: 0.969
Data Source: BioPlex,STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
p_int: 0.999880922
p_ni: 1e-9
p_wrong: 0.000119077
Score: 0.98
Data Source: BioPlex,STRINGDB
DUSP3
Tchem
Family: Enzyme
Novelty: 0.00518547
p_int: 0.755048198
p_ni: 0.244934878
p_wrong: 0.000016924
Data Source: BioPlex
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.987
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.983
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.981
Data Source: STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.979
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.979
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.979
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  405.94

PubMed score by year
PubTator Score  268.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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