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Tbio
ATG12
Ubiquitin-like protein ATG12

Protein Summary
Description
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601). Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000500945
  • ENSP00000425164
  • ENSG00000145782
  • ENST00000509910
  • ENSP00000425107

Symbol
  • APG12
  • APG12L
  • APG12
  • FBR93
  • APG12L
  • HAPG12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.85
kinase perturbation
0.81
hub protein
0.79
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.56   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 709   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.56   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 709   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (152)
1 – 10 of 152
RAB33B
Tbio
Family: Enzyme
Novelty: 0.08158789
p_int: 0.999999235
p_ni: 7.65e-7
p_wrong: 1e-9
Score: 0.507
Data Source: BioPlex,STRINGDB
ATG3
Tbio
Novelty: 0.00966067
p_int: 0.999982687
p_ni: 1.5e-8
p_wrong: 0.000017297
Score: 0.999
Data Source: BioPlex,STRINGDB
ATG10
Tbio
Novelty: 0.03086623
p_int: 0.999935135
p_ni: 7.5e-8
p_wrong: 0.00006479
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
ATG7
Tbio
Novelty: 0.00164436
Score: 0.999
Data Source: Reactome,STRINGDB
ATG5
Tbio
Novelty: 0.00108428
Score: 0.999
Data Source: Reactome,STRINGDB
BECN1
Tbio
Novelty: 0.00046615
Score: 0.997
Data Source: STRINGDB
ATG16L1
Tbio
Novelty: 0.00474887
Score: 0.996
Data Source: Reactome,STRINGDB
GABARAPL1
Tbio
Novelty: 0.00343586
Score: 0.995
Data Source: STRINGDB
GABARAPL2
Tbio
Novelty: 0.00361606
Score: 0.994
Data Source: STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00398886
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  157.56

PubMed score by year
PubTator Score  97.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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