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Tchem
NEDD4
E3 ubiquitin-protein ligase NEDD4

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338963
  • ENSP00000345530
  • ENSG00000069869
  • ENST00000435532
  • ENSP00000410613
  • ENST00000506154
  • ENSP00000422705
  • ENST00000508342
  • ENSP00000424827

Symbol
  • KIAA0093
  • NEDD4-1
  • RPF1
  • NEDD4-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
0.98
molecular function
0.98
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.78   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.78   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keloid
1
1
0
1.5
76.7
Dupuytren Contracture
1
1
0
1.2
43.3
intraocular pressure measurement
1
1
1
23.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keloid
0
1.5
76.7
Dupuytren Contracture
0
1.2
43.3
intraocular pressure measurement
1
23.9
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Antiviral mechanism by IFN-stimulated genes
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (453)
1 – 10 of 453
FAM189B
Tbio
Novelty: 0.21064304
p_int: 0.99998787
p_ni: 0.00001213
Score: 0.22
Data Source: BioPlex,STRINGDB
FAM189A2
Tdark
Novelty: 0.41335428
p_int: 0.999969242
p_ni: 0.000030758
Data Source: BioPlex
ARRDC1
Tbio
Novelty: 0.10481621
p_int: 0.999944958
p_ni: 0.000055042
Score: 0.803
Data Source: BioPlex,STRINGDB
TMEM51
Tdark
Novelty: 0.54147214
p_int: 0.999824444
p_ni: 0.000175556
Data Source: BioPlex
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.999772794
p_ni: 0.000227206
Score: 0.293
Data Source: BioPlex,STRINGDB
ILDR1
Tbio
Novelty: 0.05462229
p_int: 0.99976863
p_ni: 0.00023137
Score: 0.194
Data Source: BioPlex,STRINGDB
WBP1
Tbio
Novelty: 1.24967974
p_int: 0.998932649
p_ni: 0.001067351
Score: 0.568
Data Source: BioPlex,STRINGDB
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.998764983
p_ni: 0.001235017
Data Source: BioPlex
TMEM52B
Tdark
Novelty: 1.55824039
p_int: 0.995641453
p_ni: 0.004358547
Data Source: BioPlex
TMEM92
Tdark
Novelty: 0.72258983
p_int: 0.994525199
p_ni: 0.005474801
Score: 0.282
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  352.78

PubMed score by year
PubTator Score  237.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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