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Tbio
EYS
Protein eyes shut homolog

Protein Summary
Description
Required to maintain the integrity of photoreceptor cells. The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342421
  • ENSP00000341818
  • ENSG00000188107
  • ENST00000370621
  • ENSP00000359655
  • ENST00000393380
  • ENSP00000377042
  • ENST00000503581
  • ENSP00000424243

Symbol
  • C6orf178
  • C6orf179
  • C6orf180
  • EGFL10
  • EGFL11
  • SPAM
  • RP25
  • SPAM
  • EGFL10
  • EGFL11
  • C6orf178
  • C6orf179
  • C6orf180
  • bA74E24.1
  • dJ22I17.2
  • bA166P24.2
  • bA307F22.3
  • dJ1018A4.2
  • dJ303F19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.86
cell line
0.66
disease
0.63
phenotype
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.56   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.56   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
5
96.7
self reported educational attainment
1
2
2
84
3
2
0
1.1
78.8
1
1
1
55.3
unipolar depression
1
1
1
55.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
96.7
self reported educational attainment
2
84
0
1.1
78.8
1
55.3
unipolar depression
1
55.3
Protein Structure (0 Structures, 10 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.75
Data Source: STRINGDB
PCARE
Tbio
Novelty: 0.0915146
Score: 0.726
Data Source: STRINGDB
CERKL
Tbio
Family: Enzyme
Novelty: 0.04190552
Score: 0.685
Data Source: STRINGDB
IMPG2
Tbio
Novelty: 0.05514955
Score: 0.685
Data Source: STRINGDB
TULP1
Tbio
Family: TF
Novelty: 0.0192093
Score: 0.676
Data Source: STRINGDB
ABCA4
Tbio
Family: Transporter
Novelty: 0.00162903
Score: 0.669
Data Source: STRINGDB
PDE6A
Tclin
Family: Enzyme
Novelty: 0.02680494
Score: 0.665
Data Source: STRINGDB
RPGR
Tbio
Family: Enzyme
Novelty: 0.002733
Score: 0.66
Data Source: STRINGDB
PRPF31
Tbio
Novelty: 0.0105753
Score: 0.655
Data Source: STRINGDB
FAM161A
Tbio
Novelty: 0.066177
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.56

PubMed score by year
PubTator Score  124.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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