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Tbio
EPPIN
Eppin

Protein Summary
Description
Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. This locus represents naturally occurring read-through transcription between the neighboring SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) and WFDC6 (WAP four-disulfide core domain 6) genes. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336443
  • ENSP00000338114
  • ENSG00000101448
  • ENST00000354280
  • ENSP00000361746
  • ENST00000504988
  • ENSP00000424176
  • ENSG00000249139

Symbol
  • SPINLW1
  • WAP7
  • WFDC7
  • SPINLW1-WFDC6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
virus perturbation
0.55
microRNA
0.48
biological term
0.42
tissue
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (28)
1 – 10 of 28
SEMG1
Tbio
Novelty: 0.0161449
Score: 0.736
Data Source: Reactome,STRINGDB
ETV4
Tbio
Family: TF
Novelty: 0.00317361
Score: 0.711
Data Source: STRINGDB
UMPS
Tclin
Family: Enzyme
Novelty: 0.00848756
Score: 0.685
Data Source: STRINGDB
LTF
Tbio
Novelty: 0.00114254
Score: 0.654
Data Source: Reactome,STRINGDB
PET100
Tbio
Novelty: 0.17104943
Score: 0.616
Data Source: STRINGDB
WFDC10A
Tdark
Novelty: 0.62036702
Score: 0.582
Data Source: STRINGDB
CLU
Tbio
Novelty: 0.00054776
Score: 0.581
Data Source: Reactome,STRINGDB
SPINT4
Tdark
Family: Enzyme
Novelty: 0.44733776
Score: 0.543
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.538
Data Source: STRINGDB
WFDC9
Tdark
Novelty: 3.44827586
Score: 0.515
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.30

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer