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Tbio
CSB-PGBD3
Chimeric ERCC6-PGBD3 protein

Protein Summary
Description
Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF. This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this ...more
Uniprot Accession IDs
Gene Name
Symbol
  • CSB
  • CKN2
  • COFS
  • ARMD5
  • COFS1
  • POF11
  • RAD26
  • UVSS1
  • CSB-PGBD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.95
histone modification site profile
0.89
phenotype
0.76
cell type or tissue
0.72


Related Tools
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.58   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.58   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (118)
1 – 10 of 118
ERCC8
Tbio
Novelty: 0.02679635
Score: 0.899
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.87
Data Source: STRINGDB
ERCC5
Tchem
Family: Enzyme
Novelty: 0.00819696
Score: 0.853
Data Source: STRINGDB
ERCC2
Tbio
Family: Enzyme
Novelty: 0.00240155
Score: 0.847
Data Source: STRINGDB
ERCC4
Tbio
Family: Enzyme
Novelty: 0.01076913
Score: 0.845
Data Source: STRINGDB
XPA
Tbio
Novelty: 0.00137698
Score: 0.84
Data Source: STRINGDB
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
Score: 0.81
Data Source: STRINGDB
ERCC6
Tbio
Novelty: 0.00764502
Score: 0.808
Data Source: STRINGDB
POLR2I
Tbio
Family: Enzyme
Novelty: 0.03100605
Score: 0.801
Data Source: STRINGDB
ERCC1
Tbio
Novelty: 0.00079472
Score: 0.8
Data Source: STRINGDB
Publication Statistics
PubMed Score  75.58

PubMed score by year
PubTator Score  203.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer