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Tdark
HMGXB3
HMG domain-containing protein 3

Protein Summary
Description
This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000502717
  • ENSP00000421917
  • ENSG00000113716
  • ENST00000613459
  • ENSP00000479027

Symbol
  • KIAA0194
  • SMF
  • SMF
  • HMGX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
histone modification site profile
0.82
disease perturbation
0.79
transcription factor perturbation
0.74
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
35.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
35.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HMG-box containing 3
VGNC:4036
462186
Macaque
HMG-box containing 3
710180
Mouse
MGI:2441817
106894
Rat
RGD:1560009
361335
Dog
HMG-box containing 3
VGNC:41716
479330
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HMG-box containing 3
Macaque
HMG-box containing 3
Mouse
Rat
Dog
HMG-box containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q12766-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (19)
1 – 10 of 19
SNRPE
Tbio
Novelty: 0.02033423
Score: 0.862
Data Source: STRINGDB
SRSF5
Tbio
Novelty: 0.01658346
Score: 0.764
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.74
Data Source: STRINGDB
SNRPD2
Tbio
Novelty: 0.02519503
Score: 0.735
Data Source: STRINGDB
LSM6
Tbio
Novelty: 0.09507671
Score: 0.732
Data Source: STRINGDB
SNRPG
Tbio
Novelty: 0.1684808
Score: 0.676
Data Source: STRINGDB
ZDHHC8
Tbio
Family: Enzyme
Novelty: 0.03434357
Score: 0.636
Data Source: STRINGDB
ZDHHC5
Tbio
Family: Enzyme
Novelty: 0.05205767
Score: 0.559
Data Source: STRINGDB
PUF60
Tbio
Novelty: 0.02667356
Score: 0.554
Data Source: STRINGDB
SRRT
Tbio
Novelty: 0.00429818
Score: 0.552
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.69

PubMed score by year
PubTator Score  1.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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