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Tbio
ATP2C1
Calcium-transporting ATPase type 2C member 1

Protein Summary
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328560
  • ENSP00000329664
  • ENSG00000017260
  • ENST00000359644
  • ENSP00000352665
  • ENST00000422190
  • ENSP00000402677
  • ENST00000428331
  • ENSP00000395809
  • ENST00000504381
  • ENSP00000425320
  • ENST00000504948
  • ENSP00000423330
  • ENST00000507488
  • ENSP00000421326
  • ENST00000508532
  • ENSP00000424783
  • ENST00000510168
  • ENSP00000427461
  • ENST00000513801
  • ENSP00000422872
  • ENST00000533801
  • ENSP00000432956

Symbol
  • KIAA1347
  • PMR1L
  • HHD
  • BCPM
  • PMR1
  • SPCA1
  • hSPCA1
  • ATP2C1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.99
transcription factor perturbation
0.91
cellular component
0.78
transcription factor
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.46   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.46   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
p_int: 0.937216952
p_ni: 0.062783048
Data Source: BioPlex
TMEFF1
Tbio
Novelty: 0.11856207
p_int: 0.927225698
p_ni: 0.072774302
Score: 0.302
Data Source: BioPlex,STRINGDB
OGFOD3
Tdark
Family: Enzyme
Novelty: 0.86903294
p_int: 0.918953518
p_ni: 0.081046482
Score: 0.379
Data Source: BioPlex,STRINGDB
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.880576738
p_ni: 0.119423261
Data Source: BioPlex
F7
Tchem
Family: Enzyme
Novelty: 0.0002521
Score: 0.764
Data Source: STRINGDB
CIB3
Tbio
Novelty: 0.02793645
Score: 0.682
Data Source: STRINGDB
PPP3CB
Tbio
Family: Enzyme
Novelty: 0.02156713
Score: 0.649
Data Source: STRINGDB
SLC30A10
Tbio
Family: Transporter
Novelty: 0.00448153
Score: 0.637
Data Source: STRINGDB
ATP1B4
Tdark
Family: Transporter
Novelty: 0.08212894
Score: 0.615
Data Source: STRINGDB
SLC11A2
Tchem
Family: Transporter
Novelty: 0.00189409
Score: 0.608
Data Source: STRINGDB
Publication Statistics
PubMed Score  436.46

PubMed score by year
PubTator Score  301.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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