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Tclin
PDE6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Protein Summary
Description
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme. Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255622
  • ENSP00000255622
  • ENSG00000133256
  • ENST00000429163
  • ENSP00000406334
  • ENST00000496514
  • ENSP00000420295

Symbol
  • PDEB
  • rd1
  • PDEB
  • RP40
  • CSNB3
  • CSNBAD2
  • GMP-PDEbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.85
biological process
0.71
co-expressed gene
0.69
tissue
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.4   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 894.4   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dipyridamole
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97525
18587
Rat
RGD:1311039
289878
Dog
phosphodiesterase 6B
VGNC:44358
399653
Horse
phosphodiesterase 6B
VGNC:21249
100050793
Cow
phosphodiesterase 6B
VGNC:32680
281974
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphodiesterase 6B
Horse
phosphodiesterase 6B
Cow
phosphodiesterase 6B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35913-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Beta-catenin independent WNT signaling
Ca2+ pathway
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (174)
1 – 10 of 174
PDE6G
Tclin
Family: Enzyme
Novelty: 0.03113994
Score: 0.995
Data Source: Reactome,STRINGDB
CNGB1
Tbio
Family: IC
Novelty: 0.01034916
Score: 0.993
Data Source: STRINGDB
PDE6H
Tclin
Family: Enzyme
Novelty: 0.0524804
Score: 0.977
Data Source: STRINGDB
CNGA1
Tchem
Family: IC
Novelty: 0.00848214
Score: 0.976
Data Source: STRINGDB
GNAT1
Tbio
Novelty: 0.03042002
Score: 0.972
Data Source: Reactome,STRINGDB
GNGT2
Tbio
Novelty: 0.0468008
Score: 0.969
Data Source: STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.964
Data Source: Reactome,STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.956
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.939
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  894.40

PubMed score by year
PubTator Score  158.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer