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Tclin
CASR
Extracellular calcium-sensing receptor

Protein Classes
Protein Summary
Description
G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). The protein encoded by this gene is a plasma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000498619
  • ENSP00000420194
  • ENSG00000036828
  • ENST00000638421
  • ENSP00000492190
  • ENST00000639785
  • ENSP00000491584

Symbol
  • GPRC2A
  • PCAR1
  • CAR
  • FHH
  • FIH
  • HHC
  • EIG8
  • HHC1
  • NSHPT
  • PCAR1
  • hCasR
  • GPRC2A
  • HYPOC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
phenotype
0.81
biological term
0.78
disease
0.68
chemical
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1792.2   (req: < 5)
Gene RIFs: 357   (req: <= 3)
Antibodies: 596   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1792.2   (req: >= 5)
Gene RIFs: 357   (req: > 3)
Antibodies: 596   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 108
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
cinacalcet
chemical structure image
etelcalcetide
chemical structure image
evocalcet
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
5
5
7
99.7
4
3
2
1
74.8
eosinophil count
2
2
2
71.3
1
1
0
1.1
51.5
1
1
0
1.2
49.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
7
99.7
2
1
74.8
eosinophil count
2
71.3
0
1.1
51.5
0
1.2
49.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium sensing receptor
VGNC:7031
460628
Macaque
calcium sensing receptor
714441
Mouse
MGI:1351351
12374
Rat
RGD:2277
24247
Dog
calcium sensing receptor
VGNC:38740
488007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium sensing receptor
Macaque
calcium sensing receptor
Mouse
Rat
Dog
calcium sensing receptor
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (52)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (450)
1 – 10 of 450
NPSR1
Tchem
Family: GPCR
Novelty: 0.00562139
Score: 0.967
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.957
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.956
Data Source: STRINGDB
TAS2R16
Tbio
Family: GPCR
Novelty: 0.03181719
Score: 0.953
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.951
Data Source: STRINGDB
TAS2R38
Tbio
Family: GPCR
Novelty: 0.004625
Score: 0.948
Data Source: STRINGDB
TAS2R40
Tbio
Family: GPCR
Novelty: 0.61332466
Score: 0.945
Data Source: STRINGDB
FFAR2
Tchem
Family: GPCR
Novelty: 0.00361123
Score: 0.944
Data Source: STRINGDB
FFAR4
Tchem
Family: GPCR
Novelty: 0.00439747
Score: 0.943
Data Source: STRINGDB
LPAR5
Tchem
Family: GPCR
Novelty: 0.01883439
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  1792.20

PubMed score by year
PubTator Score  888.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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