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Tbio
ZMYND8
Protein kinase C-binding protein 1

Protein Summary
Description
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262975
  • ENSP00000262975
  • ENSG00000101040
  • ENST00000311275
  • ENSP00000312237
  • ENST00000352431
  • ENSP00000335537
  • ENST00000355972
  • ENSP00000348246
  • ENST00000360911
  • ENSP00000354166
  • ENST00000372023
  • ENSP00000361093
  • ENST00000396281
  • ENSP00000379577
  • ENST00000446994
  • ENSP00000396725
  • ENST00000458360
  • ENSP00000392964
  • ENST00000461685
  • ENSP00000418210
  • ENST00000471951
  • ENSP00000420095
  • ENST00000536340
  • ENSP00000439800
  • ENST00000540497
  • ENSP00000443086

Symbol
  • KIAA1125
  • PRKCBP1
  • RACK7
  • RACK7
  • PRKCBP1
  • PRO2893
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.99
drug perturbation
0.96
disease perturbation
0.93
PubMedID
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
2
2
2
85.8
mean platelet volume
3
1
3
83.5
depressive symptom measurement
2
2
2
79.6
1
1
0
1
68.7
unipolar depression
1
1
0
1
68.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
2
85.8
mean platelet volume
3
83.5
depressive symptom measurement
2
79.6
0
1
68.7
unipolar depression
0
1
68.7
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (74)
1 – 10 of 74
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999999958
p_ni: 4.2e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.999999862
p_ni: 1.38e-7
Data Source: BioPlex
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.999999602
p_ni: 3.98e-7
Data Source: BioPlex
LLGL2
Tbio
Novelty: 0.07084531
p_int: 0.999998388
p_ni: 0.000001612
Data Source: BioPlex
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.99999802
p_ni: 0.00000198
Data Source: BioPlex
GATAD2A
Tbio
Novelty: 0.05599551
p_int: 0.999996614
p_ni: 0.000003386
Score: 0.725
Data Source: BioPlex,STRINGDB
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999862512
p_ni: 0.000137488
Data Source: BioPlex
TSPYL1
Tbio
Novelty: 0.06381144
p_int: 0.994782981
p_ni: 0.005217004
p_wrong: 1.6e-8
Score: 0.22
Data Source: BioPlex,STRINGDB
APOD
Tbio
Novelty: 0.0031899
p_int: 0.907330299
p_ni: 0.092535296
p_wrong: 0.000134405
Data Source: BioPlex
INTS6
Tbio
Novelty: 0.02680242
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.01

PubMed score by year
PubTator Score  13.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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