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Tbio
PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Protein Summary
Description
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360525
  • ENSP00000353719
  • ENSG00000185808
  • ENST00000399098
  • ENSP00000382049
  • ENST00000399102
  • ENSP00000382053
  • ENST00000399103
  • ENSP00000382054
  • ENST00000464265
  • ENSP00000420037

Symbol
  • DCRC
  • DSCR5
  • DSCRC
  • DCRC
  • DSRC
  • DSCR5
  • PIG-P
  • DCRC-S
  • EIEE55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
virus perturbation
0.85
transcription factor binding site profile
0.82
cell type or tissue
0.78
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Metabolism of proteins (R-HSA-392499)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of glycosylphosphatidylinositol (GPI)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Synthesis of glycosylphosphatidylinositol (GPI)
Protein-Protein Interactions (58)
1 – 10 of 58
PYCARD
Tbio
Novelty: 0.00719985
p_int: 0.999876951
p_ni: 0.000123046
p_wrong: 3e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
p_int: 0.985531437
p_ni: 3e-9
p_wrong: 0.01446856
Data Source: BioPlex
PIGA
Tbio
Family: Enzyme
Novelty: 0.00172769
p_int: 0.977728954
p_ni: 0.022271041
p_wrong: 5e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
PIGH
Tbio
Family: Enzyme
Novelty: 0.0584561
p_int: 0.836992866
p_ni: 0.001149376
p_wrong: 0.161857758
Score: 0.995
Data Source: BioPlex,STRINGDB
PIGC
Tbio
Family: Enzyme
Novelty: 0.02057578
Score: 0.991
Data Source: STRINGDB
DPM2
Tdark
Novelty: 0.04752556
Score: 0.989
Data Source: STRINGDB
PIGQ
Tbio
Family: Enzyme
Novelty: 0.02701629
Score: 0.982
Data Source: STRINGDB
PIGL
Tbio
Family: Enzyme
Novelty: 0.03151013
Score: 0.981
Data Source: STRINGDB
PIGY
Tbio
Family: Enzyme
Novelty: 0.17988252
Score: 0.979
Data Source: STRINGDB
PYURF
Tdark
Novelty: 0.19841169
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.03

PubMed score by year
PubTator Score  15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer