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Tchem
MAP3K6
Mitogen-activated protein kinase kinase kinase 6

Protein Summary
Description
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357582
  • ENSP00000350195
  • ENSG00000142733
  • ENST00000374040
  • ENSP00000363152
  • ENST00000493901
  • ENSP00000419591

Symbol
  • ASK2
  • MAPKKK6
  • MEKK6
  • ASK2
  • MEKK6
  • MAPKKK6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
gene perturbation
0.88
transcription factor binding site profile
0.79
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.42   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1642655
chemical structure image
Protein-Protein Interactions (33)
1 – 10 of 33
TNFSF13B
Tclin
Novelty: 0.00048014
p_int: 0.999999892
p_ni: 1.06e-7
p_wrong: 1e-9
Data Source: BioPlex
PLEKHO2
Tdark
Novelty: 0.95238095
p_int: 0.999999797
p_ni: 2.02e-7
p_wrong: 1e-9
Score: 0.24
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.999963331
p_ni: 0.000036669
p_wrong: 1e-9
Data Source: BioPlex
HSP90AA4P
Tdark
p_int: 0.999858549
p_ni: 0.000141448
p_wrong: 3e-9
Data Source: BioPlex
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00252437
p_int: 0.999753751
p_ni: 0.000246249
Score: 0.339
Data Source: BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int: 0.998101209
p_ni: 0.001898791
Data Source: BioPlex
USP4
Tbio
Family: Enzyme
Novelty: 0.00872265
p_int: 0.997891198
p_ni: 0.001165749
p_wrong: 0.000943053
Data Source: BioPlex
LIMD1
Tbio
Novelty: 0.05230149
p_int: 0.995447148
p_ni: 0.004552609
p_wrong: 2.43e-7
Data Source: BioPlex
PCDHA4
Tdark
Novelty: 0.6
p_int: 0.990374772
p_ni: 0.009625228
Data Source: BioPlex
RNF123
Tbio
Family: Enzyme
Novelty: 0.04581752
p_int: 0.981882436
p_ni: 0.018117564
Score: 0.333
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.42

PubMed score by year
PubTator Score  14.6

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer