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Tbio
GCSAM
Germinal center-associated signaling and motility protein

Protein Summary
Description
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308910
  • ENSP00000309487
  • ENSG00000174500
  • ENST00000460387
  • ENSP00000420603
  • ENST00000484193
  • ENSP00000419485
  • ENST00000643065
  • ENSP00000493535
  • ENSG00000284925
  • ENST00000644247
  • ENSP00000494547
  • ENST00000646639
  • ENSP00000496265

Symbol
  • GAL
  • GCET2
  • HGAL
  • GCAT2
  • GCET2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
tissue sample
0.61
tissue
0.56
microRNA
0.52
cell line
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.33   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.33   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
germinal center associated signaling and motility
VGNC:9673
460581
Macaque
germinal center associated signaling and motility
707891
Mouse
MGI:102969
14525
Rat
RGD:1591321
685692
Dog
germinal center associated signaling and motility
VGNC:41152
100684299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
germinal center associated signaling and motility
Macaque
germinal center associated signaling and motility
Mouse
Rat
Dog
germinal center associated signaling and motility
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N6F7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (77)
1 – 10 of 77
NISCH
Tclin
Novelty: 0.00137246
Score: 0.64
Data Source: STRINGDB
LGALS2
Tbio
Novelty: 0.06910453
Score: 0.592
Data Source: STRINGDB
BCL6
Tchem
Family: TF
Novelty: 0.00066258
Score: 0.589
Data Source: STRINGDB
LMO2
Tbio
Novelty: 0.0038279
Score: 0.586
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.572
Data Source: STRINGDB
SERPINA9
Tbio
Novelty: 0.04989426
Score: 0.556
Data Source: STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
Score: 0.53
Data Source: STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.522
Data Source: STRINGDB
LGALS1
Tchem
Novelty: 0.00106509
Score: 0.515
Data Source: STRINGDB
SNX22
Tdark
Novelty: 0.26806147
Score: 0.494
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.33

PubMed score by year
PubTator Score  22.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer