You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CDNF
Cerebral dopamine neurotrophic factor

Protein Summary
Description
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378442
  • ENSP00000367703
  • ENSG00000185267
  • ENST00000465530
  • ENSP00000419395

Symbol
  • ARMETL1
  • ARMETL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
cell type or tissue
0.76
transcription factor binding site profile
0.74
microRNA
0.59
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.66   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.66   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (47)
1 – 10 of 47
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
p_int: 0.99998979
p_ni: 0.00001021
Score: 0.303
Data Source: BioPlex,STRINGDB
DNAJC10
Tbio
Novelty: 0.02258366
Score: 0.825
Data Source: STRINGDB
CRELD2
Tbio
Novelty: 0.09438775
Score: 0.788
Data Source: STRINGDB
HYOU1
Tbio
Novelty: 0.00833649
Score: 0.777
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.77
Data Source: STRINGDB
LRRC30
Tdark
Novelty: 2.30668103
Score: 0.759
Data Source: STRINGDB
KDELR1
Tbio
Novelty: 0.0036468
Score: 0.744
Data Source: STRINGDB
DNAJC3
Tbio
Novelty: 0.02129782
Score: 0.675
Data Source: STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.667
Data Source: STRINGDB
GDNF
Tbio
Novelty: 0.00036702
Score: 0.662
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.66

PubMed score by year
PubTator Score  23.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer