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Tbio
GFM1
Elongation factor G, mitochondrial

Protein Summary
Description
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264263
  • ENSP00000264263
  • ENSG00000168827
  • ENST00000486715
  • ENSP00000419038

Symbol
  • EFG
  • EFG1
  • GFM
  • EFG
  • GFM
  • EFG1
  • EFGM
  • EGF1
  • hEFG1
  • COXPD1
  • mtEF-G1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
kinase perturbation
0.91
transcription factor perturbation
0.91
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.33   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.33   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Translation
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (392)
1 – 10 of 392
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.881683414
p_ni: 0.118316586
Score: 0.619
Data Source: BioPlex,STRINGDB
YBEY
Tdark
Family: Enzyme
Novelty: 0.02778029
p_int: 0.860559022
p_ni: 0.139440978
Score: 0.166
Data Source: BioPlex,STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.847901453
p_ni: 0.152098547
Score: 0.333
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.843558866
p_ni: 0.156441134
Score: 0.57
Data Source: BioPlex,STRINGDB
GLB1L3
Tdark
Family: Enzyme
Novelty: 1.00833616
p_int: 0.803477487
p_ni: 0.196522513
Data Source: BioPlex
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.789950129
p_ni: 0.210049871
Score: 0.987
Data Source: BioPlex,STRINGDB
SUCLA2
Tbio
Family: Enzyme
Novelty: 0.02029861
p_int: 0.758214625
p_ni: 0.241785375
Score: 0.475
Data Source: BioPlex,STRINGDB
MRPS7
Tbio
Novelty: 0.00153134
Score: 0.997
Data Source: STRINGDB
MRPS16
Tbio
Novelty: 0.24108603
Score: 0.994
Data Source: STRINGDB
MRPS5
Tbio
Novelty: 0.11423336
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  209.33

PubMed score by year
PubTator Score  317.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer