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Tchem
BRCA1
Breast cancer type 1 susceptibility protein

Protein Summary
Description
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by bindi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352993
  • ENSP00000312236
  • ENSG00000012048
  • ENST00000357654
  • ENSP00000350283
  • ENST00000461221
  • ENSP00000418548
  • ENST00000461798
  • ENSP00000417988
  • ENST00000468300
  • ENSP00000417148
  • ENST00000471181
  • ENSP00000418960
  • ENST00000491747
  • ENSP00000420705
  • ENST00000493795
  • ENSP00000418775

Symbol
  • RNF53
  • IRIS
  • PSCP
  • BRCAI
  • BRCC1
  • FANCS
  • PNCA4
  • RNF53
  • BROVCA1
  • PPP1R53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
co-expressed gene
0.99
kinase
0.99
molecular function
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9847.2   (req: < 5)
Gene RIFs: 2045   (req: <= 3)
Antibodies: 2084   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9847.2   (req: >= 5)
Gene RIFs: 2045   (req: > 3)
Antibodies: 2084   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
41.1
2
1
0
3
32
age at menarche
1
1
1
25.4
monocyte percentage of leukocytes
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
41.1
0
3
32
age at menarche
1
25.4
monocyte percentage of leukocytes
1
18.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRCA1, DNA repair associated
VGNC:10506
449497
Macaque
BRCA1, DNA repair associated
712634
Mouse
MGI:104537
12189
Rat
RGD:2218
497672
Dog
BRCA1, DNA repair associated
VGNC:38516
403437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRCA1, DNA repair associated
Macaque
BRCA1, DNA repair associated
Mouse
Rat
Dog
BRCA1, DNA repair associated
Protein Structure (28 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P38398-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 28
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (146)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Gene Ontology Terms (81)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (801)
1 – 10 of 801
BARD1
Tbio
Novelty: 0.00513841
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CDKN3
Tbio
Family: Enzyme
Novelty: 0.00093913
p_int: 0.999999977
p_ni: 2.2e-8
p_wrong: 1e-9
Score: 0.554
Data Source: BioPlex,STRINGDB
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 0.999999789
p_ni: 4.3e-8
p_wrong: 1.68e-7
Score: 0.424
Data Source: BioPlex,STRINGDB
ABLIM3
Tdark
Novelty: 0.28184092
p_int: 0.999887057
p_ni: 0.000079891
p_wrong: 0.000033053
Data Source: BioPlex
IFI30
Tbio
Family: Enzyme
Novelty: 0.00939681
p_int: 0.999668114
p_ni: 0.000103511
p_wrong: 0.000228375
Score: 0.187
Data Source: BioPlex,STRINGDB
ABRAXAS1
Tbio
Novelty: 0.07078408
Score: 0.999
Data Source: STRINGDB
UIMC1
Tbio
Novelty: 0.02039732
Score: 0.999
Data Source: STRINGDB
BRCA2
Tbio
Novelty: 0.0002217
Score: 0.998
Data Source: Reactome,STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.997
Data Source: Reactome,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  9847.20

PubMed score by year
PubTator Score  7972.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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