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Tchem
PPP2CA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Protein Summary
Description
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000481195
  • ENSP00000418447
  • ENSG00000113575

Symbol
  • RP-C
  • PP2Ac
  • PP2CA
  • NEDLBA
  • PP2Calpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
viral protein
1
virus
1
biological process
0.99


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.77   (req: < 5)
Gene RIFs: 126   (req: <= 3)
Antibodies: 609   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.77   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 609   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
471633
Macaque
protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9299]
Mouse
MGI:1321159
19052
Rat
RGD:3380
24672
Cow
protein phosphatase 2 catalytic subunit alpha
VGNC:33251
282320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Macaque
protein phosphatase 2 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9299]
Mouse
Rat
Cow
protein phosphatase 2 catalytic subunit alpha
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (173)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 127
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Gene Ontology Terms (44)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (672)
1 – 10 of 672
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.999999918
p_ni: 8.1e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999997661
p_ni: 0.000002339
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FOXD4
Tbio
Family: TF
Novelty: 0.11166611
p_int: 0.999995916
p_ni: 0.000004084
Score: 0.161
Data Source: BioPlex,STRINGDB
PPME1
Tchem
Family: Enzyme
Novelty: 0.01559862
p_int: 0.999995129
p_ni: 0.000004871
Score: 0.998
Data Source: BioPlex,STRINGDB
PPP2R2C
Tbio
Family: Enzyme
Novelty: 0.05453128
p_int: 0.999931796
p_ni: 0.000068203
Score: 0.992
Data Source: BioPlex,STRINGDB
SERTAD4
Tdark
Novelty: 0.70786986
p_int: 0.999879879
p_ni: 0.000120121
Score: 0.669
Data Source: BioPlex,STRINGDB
TBCCD1
Tbio
Novelty: 0.21991508
p_int: 0.999833268
p_ni: 0.000166732
Data Source: BioPlex
CDCA4
Tbio
Novelty: 0.04549061
p_int: 0.999823102
p_ni: 0.000176898
Score: 0.638
Data Source: BioPlex,STRINGDB
PTPDC1
Tdark
Family: Enzyme
Novelty: 0.38792241
p_int: 0.999783148
p_ni: 0.000216852
Score: 0.522
Data Source: BioPlex,STRINGDB
NCAPD3
Tbio
Novelty: 0.02819003
p_int: 0.999772296
p_ni: 0.000227704
Score: 0.158
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  190.77

PubMed score by year
PubTator Score  191.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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