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Tbio
CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

Protein Summary
Description
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004). Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563). As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000488633
  • ENSP00000418287
  • ENSG00000144021

Symbol
  • CIA1
  • WDR39
  • CIA1
  • WDR39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.93
transcription factor perturbation
0.8
protein domain
0.73
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.18   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.18   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
Metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (106)
1 – 10 of 106
CIAO2A
Tbio
Novelty: 0.16823665
p_int: 0.999999142
p_ni: 8.58e-7
Score: 0.959
Data Source: BioPlex,STRINGDB
MMS19
Tbio
Novelty: 0.01978769
p_int: 0.99070812
p_ni: 0.00929188
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CPLX3
Tbio
Novelty: 0.07332857
p_int: 0.977050581
p_ni: 0.022949419
Score: 0.163
Data Source: BioPlex,STRINGDB
CDKAL1
Tbio
Family: Enzyme
Novelty: 0.01013607
p_int: 0.856907872
p_ni: 0.1430916
p_wrong: 5.28e-7
Score: 0.75
Data Source: BioPlex,STRINGDB
DNA2
Tbio
Family: Enzyme
Novelty: 0.00195682
p_int: 0.847181513
p_ni: 0.152818486
p_wrong: 1e-9
Score: 0.785
Data Source: BioPlex,STRINGDB
MPPED1
Tdark
Family: Enzyme
Novelty: 0.58103321
p_int: 0.841107078
p_ni: 0.158892922
Score: 0.635
Data Source: BioPlex,STRINGDB
FBXL5
Tbio
Novelty: 0.03103624
p_int: 0.787635058
p_ni: 0.212364942
Score: 0.67
Data Source: BioPlex,STRINGDB
RGS13
Tbio
Novelty: 0.11219302
p_int: 0.765398358
p_ni: 0.234601642
Score: 0.225
Data Source: BioPlex,STRINGDB
CIAO2B
Tbio
Novelty: 0.09725962
Score: 0.999
Data Source: Reactome,STRINGDB
CIAO3
Tbio
Novelty: 0.00627147
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  24.18

PubMed score by year
PubTator Score  18.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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